Pyrazolo [1,5-A]pyrimidine adenosine A 2a receptor antagonists

Details Pyrazolo [1,5-A]pyrimidine adenosine A 2a receptor antagonists Pyrazolo [1,5-A]pyrimidine adenosine A 2a receptor antagonists

2005-12-19

2010-06-22

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S575000, C544S218000, C544S228000, C514S259310, C514S233200, C514S252160

Reexamination Certificate

active

07741318

ABSTRACT:
Compounds having the structural formula Iare disclosed, whereinA is alkylene, or optionally substituted arylene, cycloalkylene or heteroaryldiyl;X is —C(O)— or —S(O)2—;R1is alkyl or cycloalkyl;R2is hydrogen, halo or —CN;R3is hydrogen or alkyl;R4is hydrogen, alkyl, alkoxy, hydroxyalkyl, aminoalkyl-, cycloalkyl, heterocycloalkyl, heterocycloalkyl substituted by alkyl, optionally substituted arylalkyl or optionally substituted heteroarylalkyl;or R3and R4, form an optionally substituted 5-7 membered ring, said ring optionally comprising an additional heteroatom ring member;R7is alkyl, optionally substituted phenyl, optionally substituted heteroaryl, cycloalkyl, halo, morpholinyl, optionally substituted piperazinyl, or optionally substituted azacycloalkyl.Also disclosed is the use of the compounds in the treatment of Parkinson's disease, alone or in combination with other agents for treating Parkinson's disease, pharmaceutical compositions comprising them and kits comprising the components of the combinations.

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PCT International Search Report mail date Sep. 1, 2006 for corresponding PCT Application No. PCT/US2005/045658.

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