Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives

Details Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives

1985-02-01

1987-04-14

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

514221, 514248, 514405, 544 61, 544119, 544232, 544235, 546199, C07D40304, C07D40104, A61K 3133

Patent

active

046580247

ABSTRACT:
Novel compounds of the formula ##STR1## wherein B represents a methylene, ethylene or vinylene group, R.sup.1 represents a hydrogen atom or an alkyl, aralkyl, amino-alkyl, mono-alkylamino-alkyl, dialkylamino-alkyl, acylamino-alkyl, phthalimido-alkyl, alkoxycarbonylamino-alkyl, aryloxycarbonylamino-alkyl, aralkoxycarbonylamino-alkyl, alkylaminocarbonylamino-alkyl, arylaminocarbonylamino-alkyl, aralkylaminocarbonylamino-alkyl, alkylsulphonylamino-alkyl or arylsulphonylamino-alkyl group, R.sup.2 represents a carboxyl, alkoxycarbonyl or aralkoxycarbonyl group or a group of the formula ##STR2## R.sup.3 represents a carboxyl, alkoxycarbonyl or aralkoxycarbonyl group, R.sup.4 and R.sup.5 each represent a hydrogen atom or R.sup.4 and R.sup.5 together represent an oxo group, R.sup.6 and R.sup.7 each represent a hydrogen atom or an alkyl or aralkyl group or R.sup.6 and R.sup.7 together with the nitrogen atom to which they are attached represent a 5-membered or 6-membered heteromonocyclic ring which may contain a further nitrogen atom or an oxygen or sulphur atom, and n stands for zero, 1 or 2, and pharmaceutically acceptable salts thereof have antihypertensive activity and can be used as medicaments in the form of pharmaceutical preparations.

REFERENCES:
patent: 4307094 (1981-12-01), Hassall et al.
patent: 4341781 (1982-07-01), Hassall et al.
patent: 4512924 (1985-04-01), Attwood et al.
Attwood et al, Chem. Abst. 100-139158j.

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