Pyrazolidinone CCK and gastrin antagonists and pharmaceutical fo

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514338, 514341, 514366, 514376, 514377, 514407, 546146, 546147, 546162, 546174, 546175, 548162, 548222, 5483111, 5483697, A61K 3147, A61K 31415, C07D23118, C07D23354

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active

056439261

ABSTRACT:
Novel substituted pyrazolidinones have been found to exhibit significant binding to cholecystokinin (CCK) receptors and gastrin receptors in the brain and/or peripheral sites such as the pancreas, stomach, and ileum. The pyrazolidinones are CCK and gastrin receptor antagonists and find therapeutic application in the treatment of gastrointestinal disorders, central nervous system disorders and for appetite regulation in warm-blood vertebrates. Pharmaceutical formulations for such indications are described.

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