Pyrazolidine derivative radical scavenger brain-infarction depre

Details Pyrazolidine derivative radical scavenger brain-infarction depre Pyrazolidine derivative radical scavenger brain-infarction depre

1996-10-30

1998-12-15

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

3483707, 3483714, 3483725, 514403, A61K 31415, C07D23118, C07D23140

Patent

active

058499300

ABSTRACT:
A pyrazolidine derivative or a salt thereof in accordance with the present invention is expressed by the following formula 1: ##STR1## wherein A represents a group expressed by --CH.sub.2 --, --CO--, --CS--, --CH.sub.2 CO--, or --CH.dbd.CH--CO--; B represents a group expressed by --O-- or --NH--; n is an integer of 1 or 2; R represents an alkenyl group; and R.sub.1 and R.sub.2 represent a lower alkyl or benzyl group.
The pyrazolidine derivative above mentioned, as a radical scavenger, has antioxidant effect and lipid peroxidation inhibitory activity so as to be available for inhibiting brain infarction or brain edema.

REFERENCES:
patent: 4207327 (1980-06-01), Lunsford et al.
patent: 4624961 (1986-11-01), Welstead, Jr.
Kornet, Ali & Steinberg J. Heterocyclic Chem. 1993.
Uchiyama, Suzuki & Fukuzawa Jap.Jr. Pharmacology 1968.
Sod, Clinical Study of Free Radical, 1987.
Jap. Journal of Stroke, 1986.

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