Pyrazole derivatives, medicinal composition containing the...

Details Pyrazole derivatives, medicinal composition containing the... Pyrazole derivatives, medicinal composition containing the...

2003-08-21

2009-12-22

Jiang, Shaojia Anna (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S406000, C514S407000, C536S017400, C548S366100, C548S370100

Reexamination Certificate

active

07635684

ABSTRACT:
The present invention provides pyrazole derivatives represented by the general formula:wherein R1represents H, an optionally substituted C1-6alkyl group etc.; one of Q and T represents a group represented by the general formula:or a group represented by the general formula:while the other represents an optionally substituted C1-6alkyl group etc.; R2represents H, a halogen atom, OH, an optionally substituted C1-6alkyl group etc.; X represents a single bond, O or S; Y represents an optionally substituted C1-6alkylene group etc.; Z represents —RB, —CORCetc. in which RBrepresents an optionally substituted C1-6alkyl group etc.; and RCrepresents an optionally substituted C1-6alkyl group etc.; R4represents H, an optionally substituted C1-6alkyl group etc.; and R3, R5and R6represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, impaired glucose tolerance, impaired fasting glycemia, diabetic complications or obesity, and a disease associated with the increase of blood galactose level such as galactosemia, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.

REFERENCES:
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patent: 1 354 888 (2003-10-01), None
Silverman, R., “The Organic Chemistry of Drug Design and Drug Action” Published 1992 by Academic Press, pp. 352-397.
2006 Chemical Abstracts catalog, published 2006 by Chemical Abstracts Service, p. 52.
Merriam-Webster's Collegiate Dictionary, tenth edition, published 1998 by Merriam-Webster, Incorporated, p. 924.
Biochemical Society Transactions, 21998, vol. 26, No. 2, p. S180 (1998).

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