Pyrazole derivatives having tyrosine kinase inhibitory activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S264100, C514S264110, C514S265100, C514S386000, C544S265000, C544S277000, C544S280000, C548S312400

Reexamination Certificate

active

07662827

ABSTRACT:
Compounds of the formula (I), in which R, X, R1, R2, R3and R4have the meanings indicated in Claim (1), are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.

REFERENCES:
patent: 2007/0259910 (2007-11-01), Halley et al.
patent: 99/23091 (1999-05-01), None
patent: 99/32106 (1999-07-01), None
patent: 99/32110 (1999-07-01), None
patent: 99/32111 (1999-07-01), None
patent: 99/32455 (1999-07-01), None
patent: WO 99/32455 (1999-07-01), None
patent: 03/029209 (2003-04-01), None
patent: 2005/121147 (2005-12-01), None
patent: 2006/043090 (2006-04-01), None
patent: WO 06/043090 (2006-04-01), None
patent: 2006/061493 (2006-06-01), None
patent: 2006/072589 (2006-07-01), None
Morissette et al. “High-throughput crystallization: polymorphs, salts, co-crystals and solvates of pharmaceutical solids.” Advanced Drug Delivery Reviews 2004, 56, 275-300.
Vippagunta, Sudha R. “Crystalline Solids.” Advanced Drug Delivery Reviews 48(2001): 3-26.

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