Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-08-25
2011-11-22
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S225200, C514S269000, C514S364000, C514S407000, C544S140000, C544S319000, C544S405000, C548S132000, C548S133000, C548S365400, C548S366100, C548S370400
Reexamination Certificate
active
08063044
ABSTRACT:
This invention relates to pyrazole derivatives of formula (I)or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives.The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodeficiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).
REFERENCES:
patent: 3303200 (1967-02-01), Wolf et al.
patent: 3963742 (1976-06-01), Cross et al.
patent: 4000301 (1976-12-01), Walworth
patent: 4041046 (1977-08-01), Cross et al.
patent: 5376645 (1994-12-01), Stella et al.
patent: 5663119 (1997-09-01), Chene et al.
patent: 6147097 (2000-11-01), Sugimoto et al.
patent: 7109228 (2006-09-01), Jones et al.
patent: 7435728 (2008-10-01), Jones et al.
patent: 2002/0150616 (2002-10-01), Vandecruys
patent: 0538156 (1992-10-01), None
patent: 0786455 (1997-07-01), None
patent: 0658547 (1998-03-01), None
patent: 665237 (1993-04-01), None
patent: WO9111172 (1991-08-01), None
patent: WO9402518 (1994-02-01), None
patent: WO9422830 (1994-10-01), None
patent: WO9429300 (1994-12-01), None
patent: WO9602138 (1996-02-01), None
patent: WO9855148 (1998-12-01), None
van Heeswijk et al., PubMed Abstract (Antivir Ther. 6(4):201-29) Dec. 2001.
Marcus et al., PubMed Abstract (Intervirology 45(4-6):260-6), 2002.
Attansi et al., J. Org. Chem., 1vol. 63, pp. 9880-9887, (1998).
Beilstein Registry No. 331922 (Update Date May 13, 1992).
Berge et al., J. Pharm. Sci., vol. 66, p. 1-19, (1977).
Bundgaard, Elsevier, Design of Prodrugs, Chapter 1, (1985).
Dzvinchuk et al., Chemical Abstracts, vol. 112: 77066, (1990).
Ferres, Drugs of Today, vol. 19., No. 9., pp. 499-538, (1983).
Genin et al., J. Med. Chem., vol. 43, p. 1034-1040, (2000).
Green and Wuts, Protective Groups in Organic Synthesis (2ndEdition), Joh Wiley and Sons, (1991).
Kato et al., Chemical Abstracts, vol. 108: 93811, (1988).
Kirsten et al., Chemical Abstracts, vol. 105:60431, (1986).
Lipinski et al., J. Med. Chem., vol. 23, pp. 1026-1031, (1980).
Munch-Peterson and Hauser, J. Am. Chem. Soc., vol. 71, pp. 770-773, (1949).
Olsen et al., J. Org. Chem., vol. 60, pp. 6025-6031, (1995).
Regitz and Schafer, Liebigs Ann. Chem., pp. 1172-1185, (1981).
Smodis and Stanovnik, Tetrahedron, vol. 54, pp. 9799-9810, (1998).
Jones Lyn Howard
Mowbray Charles Eric
Price David Anthony
Selby Matthew Duncan
Stupple Paul Anthony
Dixon J. Michael
Kispert Jennifer A.
Pfizer Inc.
Rao Deepak
LandOfFree
Pyrazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4260173