Pyrazole derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S255010, C514S236500, C514S407000

Reexamination Certificate

active

07435728

ABSTRACT:
This invention relates to pyrazole derivatives of formula (I)or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation thereof, intermediates used in their preparation of, compositions containing them and the uses of such derivatives.The compounds of the present invention bind to the enzyme reverse transcriptase and are modulators, especially inhibitors thereof. As such the compounds of the present invention are useful in the treatment of a variety of disorders including those in which the inhibition of reverse transcriptase is implicated. Disorders of interest include those caused by Human Immunodificiency Virus (HIV) and genetically related retroviruses, such as Acquired Immune Deficiency Syndrome (AIDS).

REFERENCES:
patent: 3303200 (1967-02-01), Wolf et al.
patent: 3963742 (1976-06-01), Cross et al.
patent: 4000301 (1976-12-01), Walworth
patent: 4041046 (1977-08-01), Cross et al.
patent: 6750230 (2004-06-01), Corbau
patent: 7141585 (2004-06-01), Corbau
patent: 6969728 (2005-11-01), Sneddon et al.
patent: 0204424 (2002-01-01), None
Fujiwara et al, “Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells” Antiviral Research, vol. 43, pp. 179-189 (1999).
Fine et al, “Proteasome blockers inhibitor TNF-α release by lipopolysaccharide stimulated macrophages and microglia: implications for HIV-1 dementia” Journal of Neuroimmunology, vol. 95, pp. 55-64 (1999).
Suzumura and Sawada, “Effects of Vesnarinone on Cytokine Production and Activation of Murine Microglia” Life Sciences, vol. 64(14), pp. 1197-1203 (1999).
Traber et al, “Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-α-induced□□HIV-1 replication in latently infected OM10.1 and Ach2 cells” International Immunology, vol. 11(2), pp. 143-150 (1999).
Harrison's Principles of Internal Medicine, 13th ed. © 1994 McGraw-Hill, Inc. Health Professions Division, pp. 1566-1618.
Dzvinchuk et al., Chemical Abstracts, vol. 112:77066, 1990.
Kato et al., Chemical Abstracts, vol. 108:93811, 1988.
Kirsten et al., Chemical Abstracts, vol. 105:60431, 1986.
Anderson, A, et al., “The Synthesis Of Azetidine-3-Carboxylic Acid,”J. Org. Chem.,1972, 3953-3955, vol. 37, No. 4.
Seydel, J., et al., “Mode Of Action And Quantitative Structure-Activity Correlations Of Tuberculostatic Drugs Of The Isonicotinic Acid Hydrazide Type,”J. Med. Chem.,1976, 483-492, vol. 19, No. 4.
Patentability Examination of Bollvian Patent Office dated Mar. 11, 2007 for counter-part Bolivian Patent Application No. 220072 (original in Spanish and English translation).
U.S. Appl. No. 09/899,322, filed Jul. 5, 2001, Corbau.
U.S. Appl. 10/832,920, filed Apr. 26, 2004, Corbau.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Pyrazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4012937

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.