Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-02-27
2007-02-27
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S407000, C548S366100, C548S369700, C548S370100, C548S371400, C548S371700, C548S372500, C548S374100, C548S375100, C548S376100, C548S377100
Reexamination Certificate
active
10706999
ABSTRACT:
A compound of the formula (I):wherein R1is hydrogen or lower alkyl;R2is lower alkyl, etc.;R3is lower alkoxy, etc.;R4is hydroxy, etc.;X is O, S, etc.;Y is CH or N;Z is lower alkylene or lower alkenylene; andm is 0 or 1;or salts thereof, which are useful as a medicament.
REFERENCES:
patent: 4826868 (1989-05-01), Wachter et al.
patent: 5051518 (1991-09-01), Murray et al.
patent: 5134142 (1992-07-01), Matsuo et al.
patent: 5164381 (1992-11-01), Wachter et al.
patent: 5298521 (1994-03-01), Ferro
patent: 5550147 (1996-08-01), Matsuo et al.
patent: 5670533 (1997-09-01), Matsuo et al.
patent: 6506747 (2003-01-01), Betageri et al.
patent: 2003/0162824 (2003-08-01), Krul
patent: 2005/0277678 (2005-12-01), Lohray et al.
patent: 11631339 (2004-08-01), None
patent: 1 104 759 (2001-06-01), None
patent: WO 96/14302 (1996-05-01), None
patent: WO 98/57910 (1998-12-01), None
patent: WO 00/18741 (2000-04-01), None
patent: WO 00/66562 (2000-11-01), None
patent: WO 01/81332 (2001-11-01), None
patent: WO 02/055502 (2002-07-01), None
patent: WO 03/040110 (2003-05-01), None
patent: WO 2004/050632 (2004-06-01), None
D.E. Griswold, et al., “Constitutive Cyclooxygenase (COX-1) and Inducible Cyclooxygenase (COX-2): Rationale for Selective Inhibition and Progress to Date”, Medicinal Research Reviews, vol. 16, No. 2, 1996, pp. 181-206.
K.N. Zelenin, et al., “”, Chemistry of Heterocyclic Compounds, vol. 38, No. 6, 2002, pp. 668-676.
G.W. Kauffman, et al., “QSAR andk-Nearest Neighbor Classification Analysis of Selective Cyclooxygenase-2 Inhibitors Using Topologically-Based Numerical Descriptors”, J. Chem. Inf. Comput. Sci., vol. 41, 2001, pp. 1553-1560.
P. Chavatte, et al., “Three-Dimensional Quantitative Structure-Activity Relationships of Cyclo-oxygenase-2 (COX-2) Inhibitors: A Comparative Molecular Field Analysis”, J. Med. Chem., vol. 44, 2001, pp. 3223-3230.
X. Wang, et al., “Practical Synthesis of 1,3-diaryl-5-alkylpyrazoles By A Highly Regioselective N-arylation of 3,5-disubstituted Pyrazoles with 4-fluoronitrobenzene”, Tetrahedron Letters, vol. 41, 2000, pp. 5321-5324.
K. Tsuji, et al., “Studies on Anti-Inflammatory Agents. V.1)” Synthesis and Pharmcological Properties of 3-(Difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfinyl)phenyl]pyrazole and Related Compounds, Chem. Pharm. Bull., vol. 45, No. 9, 1997, pp. 1475-1481.
K. Tsuji, et al., “Studies on Anti-Inflammatory Agents. V.1)” Synthesis and Pharmacological Properties of 1,5-Diarylpyrazoles and Related Derivatives, Chem. Pharm. Bull., vol. 45, No. 6, 1997, pp. 987-995.
T.D. Penning, et al., “Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)”, J. Med. Chem., vol. 40, 1997, pp. 1347-1365.
W. Murrary, et al., “Synthesis of 3-(1,5-Diphenyl-3-pyrazolyl)aryl Propanoates”, J. Heterocyclic Chem., vol. 27, 1990, pp. 1933-1940.
W. Murrary, et al., “A Simple Regioselective Synthesis of Ethyl 1,5-Diarylpyrazole-3-Carboxylates”, J. Heterocyclic Chem., vol. 26, 1989, pp. 1389-1392.
M. Mihalic, et al., “Synthesis of the New Indole Derivatives Related to Indomethacin”, Groatica Chemica ACTA, vol. 51, No. 1, 1978, pp. 81-92.
K. Zelenin, et al., “5-Hydroxy-4,5-Dihydropyrazoles”, Tetrahedron, vol. 51, No. 41, 1995, pp. 11251-11256.
G. Menozzi, et al., “4-Substituted 1,5-Diarylpyrazole, Analogues of Celecoxib: Synthesis and Preliminary Evaluation of Biological Properties”, Farmaco, vol. 58, 2003, pp. 795-808.
A. Alberola, et al., “Scope and Limitations in the Regioselective Synthesis of 1,3,5-Trisubstituted Pyrazoles from β-Amino Enones and Hydrazine Derivatives.13C-Chemical Shift Prediction Rules for 1,3,5-Trisubstituted Pyrazoles”, Heterocycles, vol. 55, No. 2, 2001, pp. 331-351.
B. Stanovnik, et al., “Product Class 1: Pyrazoles”, Science of Synthesis, vol. 12, 2002, pp. 15-225.
Azami Hidenori
Kayakiri Natsuko
Nakamura Katsuya
Okumura Kazuo
Shirai Fumiyuki
Astellas Pharma Inc.
Morris Patricia L.
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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