Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-09-29
1998-02-24
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548253, 5483725, A61K 31415, C07D40312
Patent
active
057212643
ABSTRACT:
##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.).
The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.
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European Journal of Pharmacology, 157 (1988), "Non-peptide angiotensin II receptor antagonists", Andrew T. Chiu et al., pp. 13-21.
Clin. and Exper. Hyper.-Theory and Practice, A4(1-2), "Inhibitors of the Renin-Angiotension System as new Antihypertensive agents" Michael J. Antonaccio, pp. 27-46 (1982).
The Journal of Pharmacology and Experimental Therapeutics, vol. 247, No. 1, "Nonpeptide Angiotensin II Receptor Antagonists. I. Pharmacological Characterization of 2-n-Butyl-4-chloro-1-(2-chlorobenzyl(imidazole--5-acetic acid, sodium salt (S-8307)", Pancras C. Wong et al., pp. 1-7 (1988).
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Higashiyama Tsutomu
Kamikawaji Yoshimasa
Masuda Yukinori
Odoi Keisuke
Sato Masayuki
Nissan Chemical Industries Ltd.
Ramsuer Robert W.
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