Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1971-12-06
1976-12-28
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
A61K 3144
Patent
active
040002810
ABSTRACT:
Pyrazole derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, methyl, ethyl, n-propyl, isopropyl, or n-butyl and X is hydrogen, hydroxy, methyl, methoxy, chlorine, or bromine, and their acid addition salts have antiviral activity against both RNA and DNA viruses such as myxoviruses, adenoviruses, rhinoviruses, and various viruses of the Herpes group. The compounds are active when administered orally or topically. They may be prepared by heating hydrazine hydrate or an alkyl hydrazine with a 3-benzofuryl ketone.
REFERENCES:
Antibiotic News, vol. 5, No. 9, Oct. 1968, pp. 1 and 3.
Merck Mawuaz, 11th edition, pp. 1268-1269 (1966).
Frobishev-Fundamentals of Microbiology, Saunders Publishers, 2nd edition, pp. 71, 79 and 80 (1962).
Frobishev-Fundamentals of Microbiology, Sanders Publishers, 8th edition, pp. 234 & 235 (1969).
Cecil et al., A Textbook of Medicine, 9th ed., W. B. Saunders Co., Phila., Pa., 1958, p. 1.
Beiler Jay Morton
Binon Fernand
Goldberg Jerome D.
Rauchfuss, Jr. George W.
Retter Eugene O.
Richardson-Merrell Inc.
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