Pyrazole derivatives

Details Pyrazole derivatives Pyrazole derivatives

1997-12-29

1998-10-06

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514381, A61K 31415, C07D40312

Patent

active

058178287

ABSTRACT:
##STR1## (wherein R.sup.1 is an alkyl group, etc.; R.sup.2 is a carboxyl group, etc.; R.sup.3 is a halogen atom, an alkyl group, a phenyl group, etc.; R.sup.4, R.sup.5 and R.sup.6 each are a hydrogen atom, a halogen atom, etc.; R.sup.7 is a carboxyl group, a 5-tetrazolyl group, etc.; X is a nitrogen atom, etc.; Y and Z each are CH, a nitrogen atom, etc.; A and E each are a methylene group, etc.; D is a phenyl group, etc.; G is a covalent bond, etc.).
The compounds of the invention have an antagonistic effect against angiotensin II and are useful for prevention and remedy of hypertension, congestive cardiac insufficiency, chronic renal insufficiency, aldosteronism, hyper-intraocular pressure, etc.

REFERENCES:
patent: 4207324 (1980-06-01), Matsumura et al.
patent: 4340598 (1982-07-01), Furukawa et al.
patent: 4576958 (1986-03-01), Wexler
patent: 4582847 (1986-04-01), Furukawa et al.
patent: 4880804 (1989-11-01), Carini et al.
patent: 5326776 (1994-07-01), Winn et al.
Clin. And Exper. Hyper.-Theory and Practice, A4(1-2), "Inhibitors of the Renin-Angiotension System as new Antilhypertensive agents" Michael J. Antonaccio, pp. 27-46 (1982).
The Journal of Pharmacology and Experimantal Therapeutics, vol. 247, No. 1, "Nonpeptide Angiotensin II Receptor Antagonist. I. Pharmacological Characterization of 2-n-Butyl-4-chloro-1-(2-chlorobenzyl(imidazole--5-acetic acid, sodium salt (s-8307)", Pancras C. Wong et al., pp. 1-7 (1988).
J. Med. Chem., vol. 36, No. 21, "A Potent Oraly Active Balanced Affinity Angiotensin II AT1 Antagonist and AT2 Binding Inhibitor", Stephen E. De Laszlo et al., pp. 3207-3210, (1993).
European Jouranl of Pharmacology, vol. 157, "Non-peptide angiotensin II receptor antagonists", Andrew T. Chiu et al., pp. 13-21, (1988).

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