Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2008-04-17
2010-02-02
McIntoshi, III, Traviss C (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S025000
Reexamination Certificate
active
07655632
ABSTRACT:
The present invention provides pyrazole derivatives represented by the general formula:wherein R1represents H, an optionally substituted C1-6alkyl group etc.; one of Q and T represents a group represented by the general formula:or a group represented by the general formula:while the other represents an optionally substituted C1-6alkyl group etc.; R2represents H, a halogen atom, OH, an optionally substituted C1-6alkyl group etc.; X represents a single bond, O or S; Y represents a single bond, a C1-6alkylene group etc.; Z represents CO or SO2; R4and R5represent H, an optionally substituted C1-6alkyl group etc.; and R3, R6and R7represent H, a halogen atom etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT1 and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.
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Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 10th Edition, McGraw-Hill Medical Publishing Division 2001 pp. 54-56.
Fushimi Nobuhiko
Isaji Masayuki
Shibazaki Toshihide
Shimizu Kazuo
Teranishi Hirotaka
Kissei Pharmaceutical Co. Ltd.
McIntoshi, III Traviss C
Sughrue & Mion, PLLC
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