Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2004-02-10
2008-09-23
Wilson, James O. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S321000, C544S320000, C544S284000, C514S275000, C514S272000, C514S266230
Reexamination Certificate
active
07427681
ABSTRACT:
This invention describes novel pyrazole compounds of formula II:wherein Z1is nitrogen or CR8; Q is —S—, —O—, —N(R4)—, or —CH(R6)—; R1is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; and Ry, R2, and R2′are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
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Bebbington David
Charrier Jean-Damien
Golec Julian
Pierard Françoise
Chung H. Joon
Truong Tamthom N
Vertex Pharmaceuticals Incorporated
Wilson James O.
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