Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-07-03
2007-07-03
Saeed, Kamal A. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S341000, C546S275400, C548S367400
Reexamination Certificate
active
10680488
ABSTRACT:
The invention provides compounds of Formula I:wherein R1, R2, R3, R4, R6, R7, R8, and A are as defined. Compounds of formula I have activity inhibiting production of Aβ-peptide. The invention also provides pharmaceutical compositions and methods for treating diseases, for example Alzheimer's disease, in mammals comprising compounds of Formula I.
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Rzepecki et al, “Prevention of Alzheimer's Disease-associated A beta Aggregation by Rationally Designed Nonpeptidic beta-Sheet Ligands” The Journal of Biological chemistry , vol. 279, No. 46, 2004, pp. 47497-47505.
Allen Martin P.
Chen Yuhpyng L.
Liras Spiros
Rosati Robert L.
Kershner David L.
Pfizer Inc
Saeed Kamal A.
Zelson Steve T.
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