Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-12-19
2006-12-19
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S313000, C514S314000, C546S153000, C546S156000, C546S157000, C546S159000, C546S162000, C546S167000
Reexamination Certificate
active
07151110
ABSTRACT:
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
REFERENCES:
patent: 0388691 (1990-09-01), None
patent: 1382603 (2004-01-01), None
patent: WO 9852937 (1998-11-01), None
patent: WO 9852941 (1998-11-01), None
patent: WO 0031063 (2000-06-01), None
patent: WO 0061576 (2000-10-01), None
patent: WO 0162756 (2001-08-01), None
patent: WO 0172737 (2001-10-01), None
patent: WO 0216359 (2002-02-01), None
patent: WO 0240468 (2002-05-01), None
patent: WO 0240476 (2002-05-01), None
patent: WO 0255077 (2002-07-01), None
patent: WO 0262787 (2002-08-01), None
patent: WO 0262794 (2002-08-01), None
patent: WO 0266462 (2002-08-01), None
patent: WO 0288107 (2002-11-01), None
patent: WO 0387304 (2003-10-01), None
patent: WO 0413135 (2004-02-01), None
J. Singh, et al., “Successful Shape-Based Virtual Screening: The Discovery of a Potent Inhibitor of the Type I TGFβ Receptor Kinase (TβRI)”,Bioorganic&Medicinal Chemistry Letters, 13 (2003) 4355-4359.
Database Crossfire Beilstein ′Online! Beilstein Institut zur Förderung der Chemischen Wissensschaften, Franfurt am Main, DE; Database accession No. 1220267, XP002262347, 2,2′-(4-phenyl-1H-pyrazole-3,5-diyl)-bis-pyridine, abstract.
Database Crossfire Beilstein ′Online! Beilstein Institut zur Förderung der Chemischen Wissensschaften, Franfurt am Main, DE; Database accession No. 1181440, XP002262348, ″2,′-[1-(3-methyl-2-phenyl-aziridin-2-yl)-4-phenyl-1H-pyrazole-3,5,-diyl)-bis pyridine, abstract.
Database Caplus ′Online! Chemical Abstracts Service, accession No. 1993:472619; Database accession No. 119:72619, XP002262349, Preparation of pyrazole and 4H-pyrazolo[1,5-a]pyrimidin-5-one derivatives as antiinflammatory, antirheumatic, antibacterial, and antiviral agents, abstract.
Database Caplus ′Online! Chemical Abstracts Service, accession No. 2000:881141, Database accession No. 134:29414, XP002262350, Preparation of substituted pyrazole compounds as p38 MAP kinase inhibitors, abstract.
Database Caplus ′Online! Chemical Abstracts Service, accession No. 1996:607249, Database accession No. 125:247806, XP002262351, Preparation of pyrazole derivatives as antiviral agents, astract.
Database Crossfire Beilstein Online, Database Accession No. 1220267, XP-002262347, Entry date: Nov. 29, 1988, Update Date: Nov. 15, 1995.
Database Crossfire Beilstein Online, Database Accession No. 1181440, XP-002262348, Entry date: Nov. 29, 1988; Update Date: Nov. 15, 1995.
Database CAPLUS Online, Accession No. 1993:472619; Database Accession No. 119:72619; XP002262349.
Database CAPLUS Online, Accession No. 2000:881141; Database Accession No. 134:29414, XP002262350.
Database CAPLUS Online, Accession No. 1996:607249; Database Accession No. 125:247806; XP002262351.
Blumberg Laura C.
Munchhof Michael J.
Ashbrook Charles W.
Goodman Rosanne
Morris Patricia L.
Pfizer Inc.
Pfizer Products Inc.
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