Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-10-25
2005-10-25
Morris, Patricia L. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S268400, C546S275400, C546S276100
Reexamination Certificate
active
06958354
ABSTRACT:
Novel pyrazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer, and fibrotic diseases.
REFERENCES:
patent: 2004/0106608 (2004-06-01), Munchhof et al.
patent: 2004/0110797 (2004-06-01), Munchhof et al.
patent: 2004/0110798 (2004-06-01), Munchhof et al.
patent: 2004/0116473 (2004-06-01), Munchhof et al.
patent: 0388691 (1990-09-01), None
patent: WO9852937 (1998-11-01), None
patent: WO9852941 (1998-11-01), None
patent: WO0031063 (2000-06-01), None
patent: WO0061576 (2000-10-01), None
patent: WO0162756 (2001-08-01), None
patent: WO0172737 (2001-10-01), None
patent: WO0216359 (2002-02-01), None
patent: WO0240468 (2002-05-01), None
patent: WO0240476 (2002-05-01), None
patent: WO0255077 (2002-07-01), None
patent: WO0262787 (2002-08-01), None
patent: WO0262794 (2002-08-01), None
patent: WO0266462 (2002-08-01), None
patent: WO0288107 (2002-11-01), None
patent: WO0387304 (2003-10-01), None
patent: WO0413135 (2004-02-01), None
Database Crossfire Beilstein Online, Database Accession No. 1220267, XP-002262347, Entry date: Nov. 29, 1988; Update Date: Nov. 15, 1995.
Database Crossfire Beilstein Online, Database Accession No. 1181440, XP-002262348, Entry date: Nov. 29, 1988; Update Date: Nov. 15,1995.
Database CAPLUS Online, Accession No. 1993:472619; Database Accession No. 119:72619; XP002262349.
Database CAPLUS Online, Accession No. 2000:881141; Database Accession No. 134:29414; XP002262350.
Database CAPLUS Online, Accession No. 1996:607249; Database Accession No. 125:247806; XP002262351.
J. Singh, et al., “Successful Shape-Based Virtual Screening: The Discovery of a Potent Inhibitor of the Type I TGFβ Receptor Kinase (TβRI)”,Bioorganic&Medicinal Chemistry Letters, 13 (2003) 4355-4359.
Blumberg Laura C.
Munchhof Michael J.
Benson Gregg C.
Morris Patricia L.
Pfizer Inc.
Sisti Nicholas J.
LandOfFree
Pyrazole compounds as transforming growth factor (TGF)... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrazole compounds as transforming growth factor (TGF)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole compounds as transforming growth factor (TGF)... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3485572