Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Acyclic nitrogen double bonded to acyclic nitrogen – acyclic...
Reexamination Certificate
2006-09-12
2006-09-12
Powers, Fiona T. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Acyclic nitrogen double bonded to acyclic nitrogen, acyclic...
C534S753000, C534S768000, C534S769000, C534S792000, C534S794000
Reexamination Certificate
active
07105503
ABSTRACT:
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, pharmaceutical compositions of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical compositions are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.
REFERENCES:
patent: WO 01/56557 (2001-09-01), None
patent: WO 01/56993 (2001-09-01), None
patent: WO 01/57022 (2001-09-01), None
Sherif et al., Chemical Abstracts, 124:146056, 1995.
Liu et al., Chemical Abstracts, 121:9222, 1994.
Wiley, Richard H., “Pyrazoles, Pyrazolines, Pyrazolidines, Indazoles and Condensed Rings”, 1967, Interscience Publishers, pp. 4-9.
Eigmele et al., Chemical Abstracts, 120:323476, 1994.
Golub et al., Science, 286, 531-537, 1999.
Baig, et al. Triazines and related products. Part 24. Synthesis of pyrazol-4-ylidenehydrazinoimidazoles by hydrazinolysis of imidazo '5, 1-cl “1,2,4triazines and 2-arylazoimidazoles by diazonium coupling reactions”, Chemical Abstracts, 97;162888, 1982.
Delcommenne, et al. “Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase”,Proc. Natl. Acad. Sci. USA, (1998) vol. 95:11211-11216.
Dubenko, et al.Chemical Abstracts, (1968) vol. 69: 18743.
Elnagdi, et al. “3,5-Pyrazolidinediones. IV. Addition of 4-arylazo-3,5-pyrazolidinediones to ethyl acrylate”, Chemical Abstracts, 79: 78677, 1973.
Elnagdi, et al. “Reaction with the arylhydrazones of some alpha.-cyano ketones”, Chemical Abstracts, 80:82349, 1974.
Elnagdi, et al. “Reactions with cyclic amidines, III: Synthesis of some new fused pyrazole derivatives”, Chemical Abstracts 91:39437, 1979.
Hassan et al. “Chemical interactions between aminopyrazoles and 2, 3-dicyano-1,4-naphthoquinone”, Chemical Abstracts, 120:8545, 1994.
Kandeel, et al. “Activated nitriles in heterocyclic synthesis: Reaction of cyanogen bromide with some functionality substituted enamines”,J. Chem. Soc. Perkin. Trans., (1985): 1499-1501.
Kandeel, et al, “Oxidative transformation of pyrazole into triazole. Novel synthesis of 4-cyano-2H-1, 2,3-triazole derivatives”, Chemical Abstracts, 108:151679, 1988.
Kitaev, et al. “Electrochemical reduction and biological activity of several 4-arylhydrazono derivatives of the 3,5-dioxopyrazoldine” Chemical Abstracts, 82:66061, 1975.
Kitaev, et al.Chemical Abstracts, (1975) vol. 82: 66061.
Liu, et al. “Synthesis of some new benzothiazolylazopyrazoles and benzothiaazolylazopyrimidines” Chemical Abstracts, 121:9222, 1994.
Rafat Mahmound, et al. “Electronic spectral properties of some arylazoaminopyrazolones”, Chemical Abstracts 101:130079, 1986.
Sherif, et al: “A convenient synthesis of polyfunctionally substituted benzo ′b !thiophen-2-yipyrimidine, -pyrazole, -isoxazole and -pyridazine derivatives”, Chemical Abstracts 124:146056, 1995.
Studennikova, et al., “3,4,5-Pyroazolidinetrione 4-arylhydrazones”, Chemical Abstracts, 105:191071, 1986.
Yuh-Wen, “Studies on the synthesis of new 3-′(3,5-diamino-1-substituted-pyrazol-4-yl) azothieno '2,3-bipyridines” Chemical Abstracts, 132:194356, 2000.
Chafeev Mikhail A.
Daynard Timothy S.
Sviridov Serguei V.
Wang Shisen
Zhang Zaihui
Powers Fiona T.
QLT Inc.
Seed IP Law Group PLLC
LandOfFree
Pyrazole compounds does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyrazole compounds, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazole compounds will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3619284