Pyrazole compositions useful as inhibitors of erk

Details Pyrazole compositions useful as inhibitors of erk Pyrazole compositions useful as inhibitors of erk

2006-06-06

2006-06-06

Lambkin, Deborah C. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S518000

Reexamination Certificate

active

07056944

ABSTRACT:
Described herein are compounds that are useful as protein kinase inhibitors having the formula:where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.

REFERENCES:
patent: 5922741 (1999-07-01), Davis et al.
patent: 5932576 (1999-08-01), Anantanarayan et al.
patent: 6528509 (2003-03-01), Hale et al.
patent: 6593357 (2003-07-01), Green et al.
patent: 6699865 (2004-03-01), Hale et al.
patent: 2 707 295 (1995-01-01), None
patent: WO 98/52941 (1998-11-01), None
Ambiter company catalog, dated Aug. 23, 1999, discloses the compound “1H-pyrrole-2-carboxamide,N,N-dimethyl-4-(4-phenyl-1 H-pyrazol-3-yl)”. Copy not available to applicants.
Jones, et al., Pyrrole studies. Part XXIII. 1,3-Dipolar addition reactions with vinytpyrroles, Heterocycles, 14(2):185-188 (1980) (see in particular p. 186, Table 1).
Zhestkov, et al., Synthesis and biological activity of pyrrole-substituted pyrazole-5-ones, Khim.-Farm. Zh., 16(6):47-52 (1982) (see in particular p. 48, Table 1).

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