Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-09-27
2005-09-27
Solola, Taofiq (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S365400
Reexamination Certificate
active
06949580
ABSTRACT:
Described herein are compounds that are useful as protein kinase inhibitors having the formula:where R1, R2, T and Ht are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
REFERENCES:
patent: 5922741 (1999-07-01), Davis et al.
patent: 2 707 295 (1995-01-01), None
patent: WO 98/52941 (1998-11-01), None
Shurov, S.N, et al., “Five-Membered-Ring 2, 3-Dioxoheterocycles. XXXV. Reaction of 5-Aryl-2, 3-Dihydro-2, 3-Furandiones with Ketene Acetals. Synthesis, Structure and Heterocyclization Reactions of 5-Aryl-Hydroxy-3-Oxo-2, 3-Dihydrofuran-2-YL Acetic Acid Alkyl Esters”, Zurnal Organiceskoj Khimii, Maik, Nauka, Moscow, RU, pp. 2275-2289 (1993).
Andreichikov, Y.S., et al., “Synthesis of 3(2,3-dihydro-3-oxo-5-pyrazolyl)-4-methyl-5-arylpyrazoles”, Zurnal Organiceskoj Khimii, Maik Nauka, Moscow, RU, 21(10):2241-2242 (1985).
Kozminykh, V.O. , Khim. Geterotsikl. Soedin., 8: 1031-1038 (1992).
Shevelev, S.A., et al., “Nitro Derivatives of Bi-, Ter-, and Quarterpyrazoles”, Russian Chem. Bulletin, Plenum, Publishing Co., NY, NY, US, 42(11):1857-1861 (1993).
Ajello, E., “New Syntheses of Condensed Heterocycles from Isoxazole Derivatives.II. Pyrazolo4, 3-B Pyridine”, J. of Heterocyclic Chemistry, heterocorporation. Provo, US, 8:1035-1037 (1971).
Polanc, S., “A Novel Method for the Annelation of the 1, 2, 4-triazole ring of the N2-C3 bond to azines”, J. Org. Chem., 39(15):2143-2147 (1974).
Monge, M.A., “An X-Ray and13C CP/MAS NMR Study of C, C-linked bipyrazoles and bispyrazolylmethanes”, Spectrochimica ACTA, 50a(4):727-734 (1994).
Hale Michael
Janetka James
Maltais Francois
Brown Karen
Solola Taofiq
Vertex Pharmaceuticals Incorporated
Vertex Pharmaceuticals Incorporated
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