Pyrazole-amides and -sulfonamides

Details Pyrazole-amides and -sulfonamides Pyrazole-amides and -sulfonamides

2007-05-29

2007-05-29

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S406000, C548S374100

Reexamination Certificate

active

10286304

ABSTRACT:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More particularly, the invention provides pyrazole-amides and -sulfonamides, compositions and methods that are useful in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrance of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a channel that includes a PN3 subunit.

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Waldrep. Thomas W. et al., “Synthesis and Herbicidal Activity of 1-Aryl-5-halo- and I-Aryl-5-(trifluoromethyl)-IH- pyrazole-4-carboxamides”; 1990, Journal of Aqricultural and Food Chemistry. vol. 38, pp. 541-544.
Wang, Alan X. et al, “Synthesis and Immunosuppressant Activity of Pyrazole Carboxamides”, 1998, Bioorganic & Medicinal Chemisty Letters, vol. 8, pp. 2787-2792.
Beck, James R. et al.; “Synthesis of 1-Aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acids and Esters”; 1987,Journal of Heterocorporation, vol. 24, No. 3, pp. 739-740.
Waldrep, Thomas W. et al.; “Synthesis and Herbicidal Activity of 1-Aryl-5-haol- and 1-Aryl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamides”; 1990,Journal of Agricultural and Food Chemistry, vol. 38, pp. 541-544.
Wang, Alan X. et al.; “Synthesis and Immunosuppressant Activity of Pyrazole Carboxamides”; 1998,Bioorganic&Medicinal Chemistry Letters, vol. 8, pp. 2787-2792.

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