Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-05-19
2000-11-14
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514253, 514255, 544405, 544408, 544 582, 544 586, 544120, 544238, 544295, 544357, A61K 31497, C07D24120, C07D40112
Patent
active
061470783
ABSTRACT:
Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: ##STR1## wherein ##STR2##
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Peter R. Bernstein, et al., "Nonpeptidic Inhibitors of Human Leukocyte Elastase . . . " J. Med. Chem., vol. 37, 1994, pp. 3313-3326.
Sanderson, et al., "Preparation of 3-amino-2-pyrazinone-1-acetamide derivatives as thrombin inhibitors," Chem. Abstracts (The Amer. Chem. Soc.), vol. 128, No. 3, pp. 532-533, 22922r, Jan. 19, 1998.
Balani Suresh K.
Sanderson Philip E.
Stanton Matthew G.
Bernhardt Emily
Merck & Co. , Inc.
Parr Richard S.
Winokur Melvin
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