Pyrazinone derivatives

Details Pyrazinone derivatives Pyrazinone derivatives

2005-07-05

2005-07-05

Wilson, James O. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S257000, C544S350000, C544S354000

Reexamination Certificate

active

06914062

ABSTRACT:
The present invention relates to a compound of the general formula (I):[Ar1is aryl fused to the adjacent pyrazinone ring at the 5th and 6th positions, etc., X is CO, etc., Y is CH, etc., Z is CH, etc., V is CH, etc., Wnis —(CH2)n— (n is zero to four), R1is H or optionally substituted lower alkyl, etc., R2is H, etc., R3and R4are the same or different and are each H, etc., R5and R6are the same or different and are each H, hydroxy, etc.] or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition, an inhibitor of Cdk4 and/or Cdk6 or an anti-cancer agent, containing the same as an active ingredient; and a process for preparing them.

REFERENCES:
patent: 1 804 328 (1969-05-01), None
patent: 0 371 564 (1990-06-01), None
patent: 97/16447 (1997-05-01), None
Lu et al, Cancer Chemotherapy Pharmacol. vol. 46, pp. 293-304 (2000).
John K. Buolamwini, Current Pharmaceutical Design, vol. 6, pp. 379-392 (2000).
Jungmann and Pfleiderer “A New Efficient Method in Nucleoside Synthesis” Tetrahedron Letters, vol. 37(46), pp. 8355-8358 (1996).
Chemical Abstracts, vol. 100, abstract No. 34499.
Chemical Abstracts, vol. 81, abstract No. 120578.

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