Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-01-11
1997-07-01
Bernhardt, Emily
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544406, A61K 31495, C07D24118
Patent
active
056439121
ABSTRACT:
Compounds of formula II ##STR1## wherein R.sup.1 is a hydrocarbon, halogenated hydrocarbon, polyether, substituted phenyl, substituted benzyl or alkylamine; and R.sup.2, R.sup.3 and R.sup.4 are hydrogen, lower alkyl, halogen, haloalkyl, alkoxy and similar substituents are disclosed. The compounds are useful in the treatment of M. avium. Methods and compositions utilizing novel as well as known compounds are disclosed.
REFERENCES:
patent: 2646431 (1953-07-01), Dalalian
patent: 2677641 (1954-05-01), Williams et al.
patent: 4051245 (1977-09-01), Ambrogi et al.
patent: 4141977 (1979-02-01), Yu et al.
patent: 4576815 (1986-03-01), Robinson
patent: 4581220 (1986-04-01), Nelson et al.
patent: 4961856 (1990-10-01), Dalton et al.
patent: 4962111 (1990-10-01), Welch et al.
patent: 5496949 (1996-03-01), Toida et al.
Grant & Hackh's Chemical Dictionary (5th Ed.) p. 24 (1987).
Organic Chemistry (3rd Ed) by Morrison and Boyd pp. 81-82 (1974).
Imperial Chemical Industries, Chemical Abstracts, vol. 101, No. 155555 (1984) (Abstract for JP59-100230, Jun. 9, 1984).
Dalton et al, Chemical Abstracts, vol. 112, No. 40123 (1990) (Abstract for EP 332314, Sep. 13, 1989).
Kushner, S. et al. "Experimental Chemotherapy of Tuberculosis, II., The Synthesis of Pyrazinamides and Related Compounds" J. Am. Chem. Soc. 74, 3617-3621 (1952).
Solomons, I. A. and Spoerri, P. E. "Esters of Pyrazionic and Pyrazine . . . " J. Am. Chem. Soc. 75, 679-681 (1953).
Kushner, S. et al., "Experimental Chemotherapy of Tuberculosis, III, Ethyl Mercaptan and Related Compounds in Tuberculosis" J. Am. Chem. Soc. 77, 1152-1155 (1954).
Brown, H. D. et all "The Antituberculosis Activity of Some Ethylmercapto Compounds" J. Am. Chem. Soc. 76, 3860 (1954).
Ul 'Yanova et al., Chem. Abst. 79, 125379t (1973).
Heifets, et al. "Pyrazinamide is not active in vitro against Mycobacterium avium Complex" Am. Rev. Resp. Dis. 134, 1287-1288 (1986).
Coker et al. "Clinical aspects of mycobacterial infections in HIV infection" Res. Microbiol. 377-381 (1992).
Cynammon, et al. "Antimycobactrial Activity of a Series of Pyrazinoic Acid Esters" J. Med. Chem. 1212-1215 (1991).
Wallace, et al. "Susceptibility Testing of Slowly Growing Mycobacteria . . . " J. Clin. Microbiol. 976-981 (1986).
Cynamon Michael Henry
Welch John T.
Bernhardt Emily
The Research Foundation of State University of NY
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