Pyrazino-carbazoles, process for the production thereof and phar

Details Pyrazino-carbazoles, process for the production thereof and phar Pyrazino-carbazoles, process for the production thereof and phar

1979-11-29

1981-03-24

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260315, 544343, A61K 31495, C07D20988, C07D49316

Patent

active

042580439

ABSTRACT:
The present invention relates to new, pharmacologically-valuable antidepressants, which are 2,4,5,6-tetrahydro-1H-pyrazino-[3,2,1-jk]-carbazoles substituted in the 8-position and having the formula I ##STR1## wherein R stands for an alkyl or alkoxy group having 1 to 4 carbon atoms or a fluorine, chlorine or bromine atom, and a method for making them by reacting with ammonia a 6,9-disubstituted 1,2,3,4-tetrahydrocarbazol-1-one of the formula II ##STR2## wherein X denotes a bromine, chlorine or iodine atom or a radical of the formula --O--SO.sub.2 --R', and R' is an alkyl radical having 1 to 3 carbon atoms, phenyl or tolyl.

REFERENCES:
Mashkovskii et al., Chem. Abs., vol 78 (1973) 124624w.
Gatta et al., Chem. Abs., vol. 83 (1975) 131553w.

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