Pyrazine kinase inhibitors

Details Pyrazine kinase inhibitors Pyrazine kinase inhibitors

2006-08-17

2010-06-15

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S408000, C548S190000, C548S371400

Reexamination Certificate

active

07737151

ABSTRACT:
The present invention relates to compounds useful as inhibitors of protein kinases of the following formula:or a pharmaceutically acceptable salt thereof. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the inventions.

REFERENCES:
patent: 3133081 (1964-05-01), Lafferty et al.
patent: 3755322 (1973-08-01), Winter et al.
patent: 3935183 (1976-01-01), Baron et al.
patent: 3998951 (1976-12-01), Harmish et al.
patent: 4051252 (1977-09-01), Mayer et al.
patent: 4493726 (1985-01-01), Burdeska et al.
patent: 4540698 (1985-09-01), Ishikawa et al.
patent: 4711951 (1987-12-01), Axen et al.
patent: 5124441 (1992-06-01), Carlsson et al.
patent: 5710158 (1998-01-01), Myers et al.
patent: 5916908 (1999-06-01), Giese et al.
patent: 5972946 (1999-10-01), Murata et al.
patent: 6093716 (2000-07-01), Davis et al.
patent: 6184226 (2001-02-01), Chakravarty et al.
patent: 6200977 (2001-03-01), Cushing et al.
patent: 6277989 (2001-08-01), Chakravarty et al.
patent: 6495582 (2002-12-01), Hale et al.
patent: 6528509 (2003-03-01), Hale et al.
patent: 6528513 (2003-03-01), Cushing et al.
patent: 6558657 (2003-05-01), Mandeville, III et al.
patent: 6562971 (2003-05-01), Frauenkron et al.
patent: 6579983 (2003-06-01), Batchelor et al.
patent: 6589958 (2003-07-01), Frietze
patent: 6593326 (2003-07-01), Bradbury et al.
patent: 6610677 (2003-08-01), Davies et al.
patent: 6613776 (2003-09-01), Knegtel et al.
patent: 6638926 (2003-10-01), Davies et al.
patent: 6642227 (2003-11-01), Cao et al.
patent: 6653300 (2003-11-01), Bebbington et al.
patent: 6653301 (2003-11-01), Bebbington et al.
patent: 6656939 (2003-12-01), Bebbington et al.
patent: 6660731 (2003-12-01), Bebbington et al.
patent: 6664247 (2003-12-01), Bebbington et al.
patent: 6696452 (2004-02-01), Davies et al.
patent: 6727251 (2004-04-01), Bebbington et al.
patent: 6743791 (2004-06-01), Cao et al.
patent: 6838464 (2005-01-01), Pease et al.
patent: 6841579 (2005-01-01), Plowman et al.
patent: 6846928 (2005-01-01), Bebbington et al.
patent: 6949544 (2005-09-01), Bethiel et al.
patent: 6989385 (2006-01-01), Bebbington et al.
patent: 7008948 (2006-03-01), Bebbington et al.
patent: 7084159 (2006-08-01), Cao et al.
patent: 7087603 (2006-08-01), Bebbington et al.
patent: 7091343 (2006-08-01), Bebbington et al.
patent: 7098330 (2006-08-01), Bebbington
patent: 7115739 (2006-10-01), Bebbington et al.
patent: 7179826 (2007-02-01), Bebbington et al.
patent: 7253187 (2007-08-01), Cao et al.
patent: 2001/0018436 (2001-08-01), Cushing et al.
patent: 2002/0052386 (2002-05-01), Armistead et al.
patent: 2002/0065270 (2002-05-01), Moriarty et al.
patent: 2003/0004161 (2003-01-01), Bebbington et al.
patent: 2003/0004164 (2003-01-01), Bebbington et al.
patent: 2003/0022885 (2003-01-01), Bebbington et al.
patent: 2003/0036543 (2003-02-01), Bebbington et al.
patent: 2003/0055044 (2003-03-01), Davies et al.
patent: 2003/0055068 (2003-03-01), Bebbington et al.
patent: 2003/0064981 (2003-04-01), Knegtel et al.
patent: 2003/0064982 (2003-04-01), Davies et al.
patent: 2003/0069239 (2003-04-01), Cai et al.
patent: 2003/0069248 (2003-04-01), Chakravarty et al.
patent: 2003/0073687 (2003-04-01), Bebbington et al.
patent: 2003/0078275 (2003-04-01), Bebbington et al.
patent: 2003/0083327 (2003-05-01), Davies et al.
patent: 2003/0087922 (2003-05-01), Bethiel et al.
patent: 2003/0092714 (2003-05-01), Cao et al.
patent: 2003/0096813 (2003-05-01), Cao et al.
patent: 2003/0096816 (2003-05-01), Cao et al.
patent: 2003/0105090 (2003-06-01), Bebbington et al.
patent: 2003/0144309 (2003-07-01), Choon-Moon
patent: 2003/0171389 (2003-09-01), Bemis et al.
patent: 2003/0187002 (2003-10-01), Mortlock et al.
patent: 2003/0199526 (2003-10-01), Choquette et al.
patent: 2003/0207873 (2003-11-01), Harrington
patent: 2003/0225073 (2003-12-01), Bebbington et al.
patent: 2004/0002496 (2004-01-01), Bebbington et al.
patent: 2004/0009974 (2004-01-01), Bebbington et al.
patent: 2004/0009996 (2004-01-01), Moon et al.
patent: 2004/0023963 (2004-02-01), Cao et al.
patent: 2004/0029857 (2004-02-01), Hale et al.
patent: 2004/0097501 (2004-05-01), Bebbington et al.
patent: 2004/0097531 (2004-05-01), Ledeboer et al.
patent: 2004/0157893 (2004-08-01), Bebbington et al.
patent: 2004/0214814 (2004-10-01), Bebbington et al.
patent: 2004/0229875 (2004-11-01), Cao et al.
patent: 2005/0004110 (2005-01-01), Bebbington et al.
patent: 2005/0038023 (2005-02-01), Bebbington et al.
patent: 2005/0234059 (2005-10-01), Hale et al.
patent: 2006/0270660 (2006-11-01), Charrier et al.
patent: 2458965 (1976-06-01), None
patent: 0019811 (1980-12-01), None
patent: 136976 (1985-04-01), None
patent: 0302312 (1989-02-01), None
patent: 2052487 (1981-01-01), None
patent: 10130150 (1998-05-01), None
patent: 2000026421 (2000-01-01), None
patent: 0665237 (2007-10-01), None
patent: 9208715 (1992-05-01), None
patent: 9322681 (1993-11-01), None
patent: 9509851 (1995-04-01), None
patent: 9515758 (1995-06-01), None
patent: 9614843 (1996-05-01), None
patent: 9709325 (1997-03-01), None
patent: 9719065 (1997-05-01), None
patent: 9802434 (1998-01-01), None
patent: 9811095 (1998-03-01), None
patent: 9814450 (1998-04-01), None
patent: 9816502 (1998-04-01), None
patent: 9838171 (1998-09-01), None
patent: 9918781 (1999-04-01), None
patent: 9941253 (1999-08-01), None
patent: 9947154 (1999-09-01), None
patent: 9962518 (1999-12-01), None
patent: 9965897 (1999-12-01), None
patent: 0012497 (2000-03-01), None
patent: 0021955 (2000-04-01), None
patent: 0038675 (2000-07-01), None
patent: 0039101 (2000-07-01), None
patent: 0042029 (2000-07-01), None
patent: 0059509 (2000-10-01), None
patent: 0078757 (2000-12-01), None
patent: 0112621 (2001-02-01), None
patent: 0125220 (2001-04-01), None
patent: 0139777 (2001-06-01), None
patent: 0140215 (2001-06-01), None
patent: 0144242 (2001-06-01), None
patent: 0147879 (2001-07-01), None
patent: 0160816 (2001-08-01), None
patent: 0164655 (2001-09-01), None
patent: 0174768 (2001-10-01), None
patent: 0179198 (2001-10-01), None
patent: 0208244 (2002-01-01), None
patent: 0218346 (2002-03-01), None
patent: 0222601 (2002-03-01), None
patent: 0224667 (2002-03-01), None
patent: 0247690 (2002-06-01), None
patent: 0250065 (2002-06-01), None
patent: 0250066 (2002-06-01), None
patent: 02059111 (2002-08-01), None
patent: 02059112 (2002-08-01), None
patent: 02066461 (2002-08-01), None
patent: 0279197 (2002-10-01), None
patent: 04000833 (2003-12-01), None
patent: 2004013140 (2004-02-01), None
Ife, R.J. et al., “Reversible Inhibitors of the Gastric (H+/K+)-ATPase. 5. Substituted 2,4-Diaminoquinazolines and Thienopyrimidines”, J. Med. Chem., 38(14); 2763-2773 (1995).
Tanzi, K. et al., “Purines. X. Reactivities of Methyl Groups on 9-Phenylpurines : Condensation with an Aldehyde or an Ester, and Oxidation with Selenium Dioxide”, Chem. Phar. Bull., 40 (1), 227-229 (1992).
Charpiot, B. et al., “Quinazolines: Combined type 3 and 4 phosphodiesterase inhibitors”, Bioorg. Med. Chem. Lett., 8 (20), 2891-2896 (1998).
Shikhaliev, K.S. et al., “Heterocyclization of quinazol-2-ylguanidines. 1. Reaction with amino acids”, Chem. Heterocycl. Compd., 35 (7), 818-820 (1999).
Singh, S.P. et al., “Synthesis & Mass Spectra of Some Substituted 2-(2′-Benzazolylamino)pyrimidines”, Indian J. Chem. Sect. B, 22(1); 37-42 (1983).
Ti, J. et al., “Anticandidal activity of pyrimidine-peptide conjugates”, J. Med. Chem., 23(8), 913-918 (1980).
Kretzschmar, E. et al., “Synthese von 2,6-disubstituierten 4-Hydroxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidinen”, Pharmazie, 43(7), 475-476 (1988).
Norman, M.H. et al., “Structure-Activity Relationships of a Series of Pyrrolo[3,2-d]pyrimidine Derivatives and Related Compounds as Neuropeptide Y5 Receptor Antagonists”, J. Med. Chem., 43(22), 4288-4312 (2000).
Nugent, R.A. et al., “Pyrimi

Affiliated with

Also associated with

Rating

Pyrazine kinase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrazine kinase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrazine kinase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4247927