Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-08-03
1989-08-22
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514824, A61K 31495
Patent
active
048596744
ABSTRACT:
Neurologic dysfunction resulting from stroke is diminished by administering to a patient an effective amount of a tetra-substituted pyrazine over a relatively continuous regimen. Conveniently, an initial bolus is administered to bring the level of the drug up to a pre-determined blood level, followed by continuous infusion employing a pump or by continuous intravenous infusion.
REFERENCES:
Conn's Current Therapy; R. E. Riskel (ed) W. B. Saunders Co., 1986.
Guo-Shi-Kui, Chen Kei-Jii Qian Zhen-Hwai, Weng Wei-Liang, Qian Mu-Ying, Tetramethylpyrazine in the Treatment of Cardiovascular and Cerebrovascular Diseases, Planta Medica 47:89 (1983).
J. A. O. Ojewole, Effects of Tetramethylpyrazine on Isolated Atria of the Guinea-Pig, (1981) 42:223-228.
J. A. O. Ojewole, Blockade of Adrenergic and Cholinergic Transmissions by Tetramethylpyrazine, (1981) 43:1-10.
Baskin et al., Naloxone Reversal of Ischaemic Neurological Deficits in Man, (Aug. 8, 1981) pp. 272-275.
Baskin et al., Naloxone Reversal and Morphine Exacerbation of Neurologic Deficits Secondary to Focal Cerebral Ischemia in Baboons, (1984) 290:289-296.
Dai et al., Coronary and Systemic Hemodynamic Effects of Tetramethylpyrazine in the Dog, (1985) 7:841-849.
Chang et al., Pharmacology and Applications of Chinese Materia Medica, (1986) pp. 131-140.
Baskin David
Lam Dominic M. K.
Friedman Stanley J.
Houston Biotechnology Incorporated
Rowland Bertram I.
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