Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-07-02
1989-07-04
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31495
Patent
active
048451010
ABSTRACT:
Chemical compounds are provided including pyrazine diazohydroxides (I), as well as methods for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. Compounds of the invention have pharmacological properties and are useful cytostatic agents and cell growth inhibiting agents. ##STR1##
REFERENCES:
Baker et al., Anti-Cancer Drug Design (1987), 2, 297-309, "Synthesis, Chemical Stability and Pre-Clinical Anti-Tumor Activity of Pyrazine Diazohydroxide, Sodium Salt (NSC-361456)".
Hirschberg et al., J. Org. Chem. 1961, 26, 1907-1912.
Bunton et al., J.A.C.B. 1974, pp. 3267-3275.
Ota et al., Chem. Abst., vol 94 (1981) 120619w.
Sogo Yakuko Co. Ltd. Chem. Abst., vol. 97 (1982) 182417z.
Watanabe et al., Chem. Abst., vol. 100 (1984) 34467f.
Baker David C.
Hand Elli S.
Haugwitz Rudiger D.
Narayanan Venkatachala L.
Rampal Jang B.
Daus Donald G.
Shen Cecilia
University of Alabama-Bd. of Trustees
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