Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-09-04
2007-09-04
Habte, Kahsay (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S238000
Reexamination Certificate
active
11087761
ABSTRACT:
A pyrazine derivative of the following formula (I):whereinR1is hydrogen or optionally substituted lower alkyl;X is hydrogen, halogen, hydroxy, cyano, acyl, or amino, aryl, heterocyclic group or the like;Y is hydrogen, halogen, hydroxy, acyl, amino, or the like;Z is aryl or heteroaryl, each of which is optionally substituted;or a salt thereof.The pyrazine compound (I) and a salt thereof of the present invention are adenosine antagonists and are useful for the prevention and/or treatment of depression, dementia (e.g. Alzheimer's disease, cerebrovascular dementia, dementia accompanying Parkinson's disease, etc.), Parkinson's disease, anxiety, pain, cerebrovascular disease (e.g. stroke, etc.), heart failure and the like.
Akahane Atsushi
Minagawa Masatoshi
Tabuchi Seiichiro
Tsutsumi Hideo
Astellas Pharma Inc.
Habte Kahsay
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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