Pyrazine derivatives

Details Pyrazine derivatives Pyrazine derivatives

2007-09-25

2007-09-25

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S255050, C514S255060, C544S295000, C544S350000, C544S405000, C544S406000, C544S407000

Reexamination Certificate

active

10699804

ABSTRACT:
1. A cyclic compound of the formula (I) or a pharmacologically acceptable salt thereof,wherein X is ═CH— or ═N—,Y is —NH—, —NR4—, —S—, —O—, —CH═N—, —N═CH—,—N═N—, —CH═CH—, etc., R1is a lower alkoxy group, an amino group, a heterocyclic ring containing N atom(s), or a hydroxy group substituted by a heterocyclic ring containing N atom(s) (each of which is optionally substituted), R2is a lower alkylamino group which is optionally substituted by an aryl group, a lower alkoxy group which is optionally substituted by an aryl group, a lower alkoxy group substituted by an aromatic heterocyclic ring containing N atom(s), R3is an aryl group, a heterocyclic ring containing N atom(s), a lower alkyl group, a lower alkoxy group, a cyclo lower alkoxy group, a hydroxy group substituted by a heterocyclic ring containing N atom(s), or an amino group (each of which is optionally substituted), and R3and a substituent in Y may be combined to form a lactone ring. The compound of the present invention has excellent selective PDE V inhibitory activity and therefore, is useful as a therapeutic or prophylactic drug for treating various diseases due to functional disorders on cGMP-signaling.

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