Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1986-12-15
1988-12-20
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514212, 514218, 5142358, 514241, 514242, 514252, 514256, 540544, 540554, 540553, 540575, 544 96, 544182, 544215, 544333, 544405, A61K 3155, A61K 31495, C07D40312, C07D40314
Patent
active
047925477
ABSTRACT:
Novel pyrazine derivatives useful for treatment of bronchial asthma, allergic gastorenteric trouble, hay fever urticaria, allertic rhinitis, and allergic conjunctivitis, and pharmaceutical compositions thereof, are disclosed. The compounds have the formula I as follows: ##STR1## wherein R represents hydrogen or ##STR2## wherein R.sub.1 and R.sub.2 may be the same or different and each independently represents hydrogen, straight or branched-chain lower-alkyl, or cycloalkyl having three to six carbon atoms inclusive, phenyl which may be substituted with halogen, lower-alkyl, or lower-alkoxy, or wherein R.sub.1 and R.sub.2 together represent alkylene of four to six carbon atoms, inclusive, optionally interrupted by one or two nitrogen atoms or one oxygen atom and said ring being optionally substituted by straight or branched-chain lower-alkyl having one to six carbon atoms inclusive, hydroxy, or phenyl,
and pharmaceutically-acceptable salts thereof.
REFERENCES:
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patent: 4404214 (1983-09-01), Takeda et al.
Honma et al., J. Med. Chem. 1984, vol. 27, No. 2, pp. 125-128.
Ford et al., J. Med. Chem. 1986, vol. 29, No. 4, pp. 538-549.
Itoh Yasuo
Kato Hideo
Koshinaka Eiichi
Mitani Kazuya
Ogawa Nobuo
Daus Donald G.
Hokuriku Pharmaceutical Co., Ltd.
Hueschen Gordon W.
Teoli, Jr. William A.
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