Pyranones

Details Pyranones Pyranones

1992-09-17

1995-08-22

Mars, Howard T.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435280, 549291, C12P 1706

Patent

active

054439710

ABSTRACT:
A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centers which comprises selective reaction of at least one isomer with a reagent catalyzed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; and

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Cardani et al., "Synthesis of Enantiomeric Pure Intermediate for the Lactone Portion of Compactin and Meyinolin" Tetrahedron, vol. 46, No. 20, pp. 7283-7288, 1990.
Enzyme Nomenclature 1978, I.U.B. (1979), pp. 232-240.
Carey et al., Adv. Org. Chem. 2nd ed.; Part A: Structure and Mechanisms (1984), pp. 69-76.

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