Pyranocoumarin derivatives

Details Pyranocoumarin derivatives Pyranocoumarin derivatives

2006-10-03

2006-10-03

Owens, Amelia A. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S282000

Reexamination Certificate

active

07115655

ABSTRACT:
The present invention relates to compounds of the following formula (I) or pharmaceutically acceptable salts thereof. The present invention also relates to use for a cognitive-enhancing agent of compounds of the following formula (I) or pharmaceutically acceptable salts thereof and to a process for preparing the same. Further, the present invention relates to use for a congnitive-enhancing agent of decursin of the following formula (II) or pharmaceutically acceptable salts thereof. In addition, the present invention relates to extracts ofAngelica gigantisRadix comprising decursin of the following formula (II), having cognitive-enhancing effects.

REFERENCES:
patent: WO 00/23074 (2000-04-01), None
patent: WO 01/52841 (2001-07-01), None
Konoshima, Masao et al ‘Coumarins from the root ofAngelica gigas’ CA 69:103778 (1968).
Ringman, Metrifonate: update on a new antidementia agent, PMID: 10584768.
Doody, Clinical benefits of a new piperidine-clas AchE inhibitor, PMID: 10332937.
Kang, S.Y. et al. “Coumarins Isolated fromAngelica gigasInhibit Acetylcholinesterase: Structure—Activity Relationships”,J. Nat. Prod. (2001) 64:683-685.

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