Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1989-02-01
1990-02-13
Gerstl, Robert
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
544238, 546197, 548126, C07D49804, A64K 3141
Patent
active
049007521
ABSTRACT:
A compounds of the formula (I): ##STR1## wherein A represents OH or OC(O)CH.sub.3-n X.sub.n, B represents hydrogen atom, or A and B together represent a bond; R.sup.1 represents hydrogen atom, R.sup.2 represents hydrogen atom, C(Z)CH.sub.3-n X.sub.n or C(Z)NHCH.sub.3-n X.sub.n or R.sup.1 and R.sup.2 together represents (CH.sub.2).sub.m, (CH.sub.2).sub.m-1 C(Z), N(R.sup.3)(CH.sub.2).sub.2 C(Z), (CH.sub.2).sub.m-2 NHC(Z) or (CH.sub.2).sub.m-2 OC(Z) in which X represents fluorine atom, chlorine atom, bromine atom, a methyl group or a methoxy group and n represents 0 or an integer of 1 to 3, Z represents oxygem atom or sulfur atom, m represents an integer of 4 or 5 and R.sup.3 represents hydrogen atom or a methyl group, and pharmacological acceptable salts of the compounds which can form salts, processes therefor and pharmaceutical use of the compounds.
REFERENCES:
patent: 4470135 (1984-10-01), Neuman
T. C. Hamilton, Sheila W. Weir & A. H. Weston, Br. J. Pharmac (1986), 88, pp. 103-111, Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.--Beecham Pharma., Research Div.,--University of Manchester.
S. L. Allen, J. P. Boyle, J. Cortijo, R. W. Foster, G. P. Moran & R. C. Small, Br. J. Pharmac. (1986) 89, pp. 395-405, Electrical and mechanical effects of BRL34915 in guinea-pig isolated trachealis-Smooth Muscle Research Grp., Dept of Pharmacology--University of Manchester.
K Channel Blocker Supersensitivity--pp. 425-431.
M. Hollingsworth, T. Amedee, Diane Edwards, J. Mironneau, J. P. Savineau, R. C. Small & A. H. Weston, The relaxant action of BRL 34915 in rat uterus, Br. J. Pharmac (1987). 91, pp. 803-813,--Smooth Muscle Research Group, Dept. of Physiological Sciences, University of Manchester.
Drug License Opportunities IMS World Publications Ltd., News Round Up, 9/7/87, No. 312.
Kamikawaji Yoshimasa
Masuda Yukinori
Matsumoto Hiroo
Nakayama Kyoko
Ohrai Kazuhiko
Gerstl Robert
Nissan Chemical Industries Ltd.
LandOfFree
Pyranobenzoxadiazole derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pyranobenzoxadiazole derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyranobenzoxadiazole derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1168446