Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1991-07-08
1993-12-21
Ivy, C. Warren
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548126, C07D40304, C07D27112
Patent
active
052722716
ABSTRACT:
A compound of the formula (I): ##STR1## wherein X.sup.1 and X.sup.2 do not exist or represent oxygen atom; A represents OH or acyloxy group having 1 to 4 carbon atoms; B represents hydrogen atom; A and B together represent a bond; R.sup.1 and R.sup.2 represent hydrogen atom or alkyl group having 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 together represent 1,2-ethylene, 1,3-propylene, 1,4-butylene or 1,5-pentylene, and these alkylene groups may be substituted by alkyl group having 1 to 4 carbon atoms; R.sup.3 represents amido group of the formula: ##STR2## wherein n, R.sup.4, R.sup.5, R.sup.6, R.sup.7. R.sup.8. R.sup.9, R.sup.10 and R.sup.11 represent specific groups, and the pharmacological acceptable salts of the compounds which can form salts have strong activity for lowering blood pressure, and process therefor and pharmaceutical use of the compounds.
REFERENCES:
patent: 4900752 (1990-02-01), Seto
Burger, A. "Medicinal Chemistry" 1960 2nd Ed. Interscience Pub. pp. 565, 566, 568, 580, 600, 601.
Hackh's "Chemical Dictionary" 1983 p. 16.
Kamikawaji Yoshimasa
Masuda Yukinori
Matsumoto Hiroo
Ohdoi Keisuke
Ohrai Kazuhiko
Chang Celia
Ivy C. Warren
Nissan Chemical Industries Ltd.
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