Pyrano[f]quinoline derivatives and pharmaceutical compositions c

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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Details

514381, 546 89, 548250, C07D49106, A61K 3144

Patent

active

050933396

ABSTRACT:
Pyrano[f]quinoline derivatives of the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen, hydroxyl group or a group of the formula: ##STR2## wherein n represents an integer from 1 to 4, R.sub.3 and R.sub.4 represent hydrogen or a lower alkyl group, and the broken lines in the rings represent that the bond between the carbon atoms at the 1- and 2-positions and the bond between the carbon atoms at the 9- and 10-positions may be double bonds, and pharmaceutical compositions containing the derivatives. The derivatives and compositions are useful as anti-thrombotic agents, cerebral circulation improving agents, hypotensive agents, anti-angina agents, anti-asthmatic agents, anti-ulcer agents and anti-PAF agents.

REFERENCES:
Otsuka Pharm. Co., "Carbostyril Derivatives", CA 98:143287h (1983).
Takao et al., "Studies of 2-Oroquinoline . . . ", CA 103:141893a (1985).

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