Pyrano- and thiopyranoindole derivatives, compositions and metho

Details Pyrano- and thiopyranoindole derivatives, compositions and metho Pyrano- and thiopyranoindole derivatives, compositions and metho

1975-03-05

1977-01-18

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602471L, 2602471P, 260268TR, 2603265SA, 26032628, 42424851, 424251, 424267, 424274, C07D49504

Patent

active

040039137

ABSTRACT:
Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substituents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano-and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.

REFERENCES:
patent: 3778449 (1973-12-01), Jirkovsky et al.
patent: 3910954 (1975-10-01), Jirkovsky et al.

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