Pyrane derivatives as both ACE-and NEP-inhibitors

Details Pyrane derivatives as both ACE-and NEP-inhibitors Pyrane derivatives as both ACE-and NEP-inhibitors

2006-07-04

2006-07-04

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07071169

ABSTRACT:
Compounds of the formula (I), wherein R1, R1–R7and alk have meaning as defined, pharmaceutical compositions thereof, and use thereof for the treatment and/or prevention of cardiovascular disorders responsive to ACE and NEP inhibition and/or ECE inhibition.

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Tsuda et al., Journal of Antibiotics Research Association, vol. 49, No. 9, (1996), Poststatin, a New Inhibitor of Endopeptidase V. Endopeptidase Inhibitory Activity of Poststatin Analogues.

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