Pygopus in diagnosis and treatment of cancer

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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C435S007100

Reexamination Certificate

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07635560

ABSTRACT:
Expression of pygopus mRNA and Pygopus protein in established cancer cell lines and in patient tumors is described. Pygopus is shown to be a feasible diagnostic and prognostic indicator. Pygopus is also useful in cancer treatment therapy, for example in disrupting strategies that specifically target the activity of pygopus in cancer cells.

REFERENCES:
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 5004810 (1991-04-01), Draper
patent: 5087617 (1992-02-01), Smith
patent: 5098890 (1992-03-01), Gewirtz et al.
patent: 5135917 (1992-08-01), Burch
patent: 5166195 (1992-11-01), Ecker
patent: 5194428 (1993-03-01), Agrawal et al.
patent: 5264423 (1993-11-01), Cohen et al.
patent: 5276019 (1994-01-01), Cohen et al.
patent: 5286717 (1994-02-01), Cohen et al.
patent: 5366866 (1994-11-01), Xu et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5484704 (1996-01-01), Dunbar
patent: 5645995 (1997-07-01), Kieback
patent: 5871941 (1999-02-01), Auersperg
patent: 5932435 (1999-08-01), Atkins et al.
patent: 6048528 (2000-04-01), Dunbar
patent: 6072034 (2000-06-01), Kaufman et al.
patent: 6277563 (2001-08-01), Shayesteh et al.
patent: 6300492 (2001-10-01), Korneluk et al.
patent: 6350615 (2002-02-01), Kaufman et al.
patent: 6376654 (2002-04-01), Gelber
patent: 6468546 (2002-10-01), Mitcham et al.
patent: 6468758 (2002-10-01), Benson et al.
patent: 6475732 (2002-11-01), Shayesteh et al.
patent: 6488931 (2002-12-01), Mitcham et al.
patent: 6512102 (2003-01-01), Xu et al.
patent: 6943241 (2005-09-01), Isogai et al.
patent: 2001/0016651 (2001-08-01), Kennedy
Thompson et al (Nature Cell Biol. 4: 367-373, 2002).
McShane, L.M., Altman, D.G., Sauerbrei, W., Taube, S.E., Gion, M., Clark, G.M., for the statistics subcommittee of the NCI-EORTC working group on cancer diagnostics. REporting recommendations for tumor MARKer prognostic studies (REMARK). 2005. European Journal of Cancer. vol. 41, pp. 1690-1696.
Andrews, P.G.P., Lake, B.B., Popadiuk, C., and Kao, K.R. Requirement of Pygopus 2 in breast cancer. 2007. International Journal of Oncology. vol. 30 No. 2, pp. 357-363.
Aasland R, Gibson TJ and Stewart AF. (1995).Trends Biochem Sci,20, 56-59.
Aksan, I. & Stinson, J. A. (2002)Trends Biochem. Sci.27, 387-389.
Amit, S. et al. Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.Genes Dev.16, 1066-1076 (2002).
Baker BF, Condon TP, Koller E, McKay RA, Siwkowski AM, Vickers TA and Monia BP. (2001).Methods,23, 191-198.
Belenkaya, T.Y. et al. pygopus Encodes a nuclear protein essential for wingless/Wnt signaling.Development129, 4089-4101 (2002).
Bienz and Clevers. Cell 103: 311-320. Oct. 13, 2000.
Brown AM. (2001).Breast Cancer Res,3, 351-355.
Cadigan, K. M. (2002)Trends Genet.18, 340-342.
Chou, Y.Y. et al. Differentiation of ovarian mucinous carcinoma and metastatic colorectal adenocarcinoma by immunostaining with beta-catenin.Histopathology43, 151-156 (2003).
Clevers H. (2002).Mol Cell,10, 1260-1261.
Cliffe, A., Hamada, F. & Bienz, M. (2003)Curr. Biol.13, 960-966.
Coqueret O. (2002).Gene,299, 35-55.
Davies, B. R., Worsley, S. D. & Ponder, B. A. (1998)Histopathology32, 69-80.
Delcommenne M, Tan C, Gray V, Rue L, Woodgett J and Dedhar S. (1998).Proc Natl Acad Sci U S A,95, 11211-11216.
Dhar, K. K., Branigan, K., Parkes, J., Howells, R. E., Hand, P., Musgrove, C., Strange, R. C., Fryer, A. A., Redman, C. W. & Hoban, P. R. (1999)Br. J. Cancer81, 1174-1181.
Doble, B. W. & Woodgett, J. R. (2003)J. Cell Sci.116, 1175-1186.
Fanto, M. & McNeill, H. Planar polarity from flies to vertebrates.J. Cell Sci.117, 527-533 (2004).
Furuuchi K, Tada M, Yamada H, Kataoka A, Furuuchi N, Hamada J, Takahashi M, Todo S and Moriuchi T. (2000).Am J Pathol,156, 1997-2005.
Gao, Z.H., Seeling,J.M., Hill,V., Yochum,A., & Virshup,D.M. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.Proc. Natl. Acad. Sci. U.S.A.99, 1182-1187 (2002).
Giles RH, van Es JH and Clevers H. (2003).Biochim Biophys Acta,1653, 1-24.
Greaves. Nature Cell Biol. 4:E124. May 2002.
Green DW, Roh H, Pippin J and Drebin JA. (2000).J Am Coll Surg,191, 93-105.
He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B and Kinzler KW. (1998).Science,281, 1509-1512.
Henderson, B.R. Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover.Nat. Cell Biol.2, 653-660 (2000).
Holnthoner W, Pillinger M, Groger M, Wolff K, Ashton AW, Albanese C, Neumeister P, Pestell RG and Petzelbauer P. (2002).J Biol Chem,277, 45847-45853.
Howe LR and Brown AM. (2004).Cancer Biol Ther,3: 36-41.
Huelsken, J. & Behrens, J. The Wnt signalling pathway.J. Cell Sci.115, 3977-3978 (2002).
http://www2.mrc-lmb.cam.ac.uk/research/CB/Bienz.M/BienzM.html [2 page print-out], 2006.
Ju ST, Panka DJ, Cui H, Ettinger R, el Khatib M, Sherr DH, Stanger BZ and Marshak-Rothstein A. (1995).Nature,373, 444-448.
Kikuchi, A. (2003)Cancer Sci.94, 225-229.
Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M and Kikuchi A. (1999).Mol Cell Biol,19, 4414-4422.
Kishida, S. et al. Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin.J. Biol. Chem.273, 10823-10826 (1998).
Klingensmith J, Nusse R and Perrimon N. (1994).Genes Dev,8, 118-130.
Korinek et al. Science 275: 1784-1787. 1997.
Kramps, T. et al. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.Cell109, 47-60 (2002).
Kuhl, M. The WNT/Calcium pathway: biochemical mediators, tools and future requirements.Front Biosci.9, 967-974 (2004).
Kuhnert, F. et al. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1.Proc. Natl. Acad. Sci. U.S.A..101, 266-271 (2004).
Lake BB and Kao KR. (2003).Dev Biol,261, 132-148.
Lake et al. Development. 128(2): 263-273. Jan. 2001 (Abstract).
Lepourcelet, M., Chen, Y. N., France, D. S., Wang, H., Crews, P., Petersen, F., Bruseo, C., Wood, A. W. & Shivdasani, R. A. (2004)Cancer Cell5, 91-102.
Li, Y. et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.Proc. Natl. Acad. Sci. U. S. A100, 15853-15858 (2003).
Li, H., Pamukcu, R. & Thompson, W. J. (2002)Cancer Biol. Ther.1, 621-625.
Lim SC and Lee MS. (2002).Oncol Rep,9, 915-928.
Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG and Hung MC. (2000).Proc Natl Acad Sci U S A,97, 4262-4266.
Lustig B and Behrens J. (2003).J Cancer Res Clin Oncol,129, 199-221.
Miller, J.R., Hocking,A.M., Brown,J.D., & Moon,R.T. Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2+ pathways.Oncogene18, 7860-7872 (1999).
Moon, R.T., Bowerman,B., Boutros,M., & Perrimon,N. The promise and perils of Wnt signaling through beta-catenin.Science296, 1644-1646 (2002).
Muratovska A, Zhou C, He S, Goodyer P and Eccles MR. (2003).Oncogene,22, 7989-7997.
Nagahata T, Shimada T, Harada A, Nagai H, Onda M, Yokoyama S, Shiba T, Jin E, Kawanami O and Emi M. (2003).Cancer Sci,94, 515-518.
NCBI Sequence Accession No. AY141128 Lake and Kao. Oct. 21, 2002.
NCBI Sequence Accession No. AY141129 Lake and Kao. Oct, 21, 2002.
NCBI Sequence Accession No. AF521655 Belenkaya et al. Aug. 14, 2002.
NCBI Sequence Accession No. AAM94597 Belenkaya et al. Aug. 14, 2002.
Nusse R and Varmus HE. (1982).Cell,31, 99-109.
Orsulic, S., Huber,O., Aberle,H., Arnold,S., & Kemler,R. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation.J. Cell Sci.112 ( Pt 8), 1237-1245 (1999).
Palacios, J. & Gamallo, C. (1998)Cancer Res.58, 1344-1347.
Parker, D.S., Jemison, J., & Cadigan, K.M. Pygopus, a nuclear PHD-finger protein required for Wingless signaling in Drosophila.Development129, 2565-2576 (2002).
Polakis P. (2000).Genes Dev,14, 1837-1851.
Polesskaya, A., Seale,P., & Rudnicki,M.A. Wnt signaling induces the myogenic spec

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