Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2006-11-28
2006-11-28
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C424S184100
Reexamination Certificate
active
07141363
ABSTRACT:
This invention relates to methods and compositions for modulating movement of eukaryotic cells with migratory capacity. More specifically, the invention relates to methods and compositions for modulating movement of cells of hematopoietic, neural, epithelial, or mesenchymal origin, in a specific site in a subject. The foregoing are useful, inter alia, in the treatment of conditions characterized by a need to modulate migratory-cell movement associated with specific sites in a subject. More specifically, specific sites include sites of inflammation and modulation of migratory-cell movement is movement away from an agent source, or repulsion. Other sites include tumor sites, sites of pathogenic infection, and germ cell bearing sites.
REFERENCES:
patent: 4737413 (1988-04-01), Buchanan
patent: 5514555 (1996-05-01), Springer et al.
patent: 5621671 (1997-04-01), Bodnar
patent: 5756084 (1998-05-01), Honjo et al.
patent: 5994298 (1999-11-01), Tsai et al.
patent: 6238874 (2001-05-01), Jarnagin et al.
patent: 6399569 (2002-06-01), Cohen et al.
patent: 6448054 (2002-09-01), Poznansky
patent: 2002/0098187 (2002-07-01), Ferrara et al.
patent: 2002/0131953 (2002-09-01), Takashima et al.
patent: 2706771 (1994-12-01), None
patent: 2151924 (1985-07-01), None
patent: WO 95/07985 (1995-03-01), None
patent: WO 98/09642 (1998-03-01), None
patent: WO 00/9678 (2000-02-01), None
patent: WO 00/59941 (2000-10-01), None
Bagnard et al. Semaphorins act as attractive and repulsive guidance signals during the development of cirtical projects. Development (1998) 125: 5043-5053.
Shioi et al. Oxygen as attractant and repellent in bacterial chemotaxis. J. Bacteriol. (1987) 169(7):3118-3123.
Klein et al. Perlecan in human bone marrow: A growth-factor-presenting, but anti-adhesive, extracellular matrix component for hematopoietic cells. Matrix Biol. (1994) 14: 457-465.
Zaitseva et al. “CXCR4 and CCR5 on Human Thymocytes: Biological Function and Role in HIV-1 Infection,” J. Immunol. (Mar. 1998) 161: 3103-3113.
Murakami et al., “A Small Molecule CXCR4 Inhibitor that Blocks T Cell Line-tropic HIV-1 Infection”,J Exp Med, 186(8); 1389-1393, 1997.
Poznansky et al., “Thymocyte emigration is mediated by active movement away from stroma-derived factors”,J Clin Invest, 109(8):1101-1110, 2002.
Poznansky et al., “Active movement of T cells away from a chemokine”,Nat Med, 6(5):543-548, 2000 Abstract Only.
Poznansky et al., “Tissue source dictates lineage outcome of human fetal CD34(+) CD38(−) cells”,Exp Ilematol, 29(6):766-774, 2001 Abstract Only.
Poznansky et al., “Efficient generation of human T cells from a tissue-engineered thymic organoid”,Nat Biotechnol, 18(7):729:734, 2000 Abstract Only.
Olszak, et al., “Extracellular calcium elicits a chemokinetic response from monocytes in vitro and in vivo”,J Clin Invest, 105(9):1299-1305, 2000 Abstract Only.
Poznansky et al., “Inhibition of human immunodeficiency virus replication and growth advantage of CD4+ T cells and moncytes derived from CD34+ cells transduced with an intracellular antibody directed against human immunodeficiency virus type 1 Tat”,Hum Gene Ther, 10(15):2505-2514, 1999 Abstract Only.
Adams et al., “Isolation and transduction of CD34+ cells from small quantities of peripheral blood from HIV-1-infected patients not treated with hemopoietic growth factors”,J Acquir Immune Defic Syndr, 21(1):1-8, 1999 Abstract Only.
Adams et al., “Heterologous cells cooperate to augment stem cell migration, homing, and engraftment”,Blood, 101(1):45-51, 2003 Abstract Only.
Niggemann, et al., “Locomotory phenotypes of human tumor cell lines and T lymphocytes in a three-dimensional collagen lattice.”Cancer Lett., Oct. 14;118(2):173-80 (1997).
Luster, “Chemokines—Chemotactic Cytokines That Mediate Inflammation”,Mechanisms of Disease, 338(7):436-445, 1998.
Baggiolini, “Chemokines and leukocyte traffic”,Nature, 392:565-568, 1998.
Bleul. et al. “A highly efficacious lymphocyte chemoattractant, stromal cell derived factor 1 (SDF-1)”J Exp Med184(3):1101-1109, 1996.
Bleul et al., “The lymphocyte chemoattractant SDF- is a ligand for LESTR/ fusion and blocks HIV-1 entry”,Nature, 382(6594):829-833, 1996.
Kim et al., “Differential Chemotactic Behavior of Developing T Cells in Response to Thymic Chemokines”,Blood, 91(12) 4434-4443, 1998.
Kim et al. “CKβ-11/Macrophage Inflammatory Protein-3β/EB1:1-Ligand Chemokine Is an Efficacious Chemoattractant for T and B Cells”J Immunol, 160:2418-2424, 1998.
Colamarino et al., The Axonal Chemoattractant Netrin-1 Is Also a Chemorepellent for Trochlear Motor Axons,Cell, 81:621-629, 1995.
Wells et al., “Definition, function and pathophysiological significance of chemokine receptors”,TiPS19:376-380, 1998.
Arakaki et al., “T134, a Small-Molecule CXCR4 Inhibitor, Has No Cross-Drug Resistance with AMD3100, a CXCR4 Antagonist with a Different Structure”,J Virol73(2):1719-1723, 1999.
Heveker et al., “Dissociation of the signaling and antiviral properties of SDF-1-derived small peptides”,Current Biol, 8(7):369-376, 1998.
Loetscher et al., “N-terminal Peptides of Stromal Cell-derived Factor-1 with CXC Chemokine Receptor 4 Agonist and Antagonist Activities”,J Biol Chem, 273(35):22279-22283, 1998.
Luo et al., “Attachment of C-Terminus of SDF-1 Enhances the Biological Activity of Its N-Terminal Peptide”,Biochem Biophys Res Commun, 264(1):42-47, 1999.
Bailey, et al., “Chemotaxis by Entamoeba Histolytica”J. Protozool(1985) 32(2):341-346. Abstract.
Berman, et al., “Functional characteristics of histamine receptor-bearing mononuclear cells. II. Identification and characterization of two histamine-induced human lymphokines that inhibit lymphocyte migration.”J Immunol., Sep.133(3):1495-504 (1984).
Chaffin, K.E. and Perlmutter, R.M. “A Pertussis Toxin-Sensitive Process Controls Thymocyte Emigration”Eur. J. Immunol.(1991) 21(10):2565-73. Abstract.
Friedl, et al., “Locomotor recruitment and negative chemotaxis of human T lymphocytes confronted with autologous primary cancer explants in three-dimensional (3-D) collagen lattices in vitro”,Proceedings of the America Assoc. for Cancer Res. Annual.37:446 (1996). Abstract.
Gebhard, et al., “Inter-alpha-trypsin inhibitor complex component II precursor-human”,PIR Protein Sequence.
Keating, M.T. and Bonner, J.T. “Negative Chemotaxis in Cellular Slime Molds”J. Bacteriol.(1977) 130(1):144-147 Abstract.
Khan, et al., “Chemotactic Signal Integration in Bacteria”Proc. Natl. Acad. Sci.USA (1995) 92(21):9757-9761 Abstract.
Keller, et al., “Diverging effects of chemo tactic serum peptides and synthetic formylmethionylleucyl phenyl alanine on neutrophil loco motion and adhesion”,Immunology, 42(3):379-384 (1981) Abstract.
Laster, et al., “Target-induced changes in macrophage migration may explain difference in lytic sensitivity among simian virus 40- transformed fibroblasts”,J Immunol.141(1):221-7 (1998) Abstract.
Liu, et al., “Analysis of chemokine (S) produced by mouse thymic stromal cell lines” Shih Yen Sheng Wu Hsuch Pao. Mar. 1996;29(1):25-32. Chinese Abstract.
McFadden, et al., “Rat lymphokines control the migration of nonsensitized lymphocytes”,Cellular Immunology, 118(2):345-357 (1989) Abstract.
Bardom et al. “Nonoterpenes Inhibit Cell growth, Cell Cycle, Cell Progression, and Cycline D1 Gene Expression in Human Breast Cancer Cell Lines.” Nutrition and Cancer 32(1), 1-7 (1998).
Yang et al. “Efficient Lysis of Human Immunodeficiency Virus Type 1-Infected Cells by Cytotoxic T Lymphocytes.” Journal of Virology (1996) 5799-5806.
Cao et al. “Cytotoxic T-Lymphocyte Cross-Reactivity among Different Human Immunodeficiency Virus Type-1 C
Luster Andrew D.
Poznansky Mark C.
Scadden David T.
Edwards Angell Palmer & & Dodge LLP
Hanley Susan
Leahy Amy M.
The General Hospital Corporation
Witz Jean C.
LandOfFree
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