Purinyl and pyrimidinyl cyclobutanes and their use as antiviral

Details Purinyl and pyrimidinyl cyclobutanes and their use as antiviral Purinyl and pyrimidinyl cyclobutanes and their use as antiviral

1988-12-20

1990-04-17

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514243, 514258, 514261, 514274, 514 81, 544244, 544254, 544265, 544277, 544280, 544313, 544314, 544317, 544264, 544276, 546 23, 546118, 549546, A61K 31395, A61K 31495, C07D47300, C07F 902

Patent

active

049180754

ABSTRACT:
Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## and R.sub.1 is either a purine, pyrimidine or an analog thereof.

REFERENCES:
patent: 4543255 (1985-09-01), Shealy et al.
Hoshino et al., Inhibition of Infectivity of Human Immunodifficiency Virus by Oxetanocin, J. Antibiotics, 40 (7), 1077 (1987).
Shimada et al., Oxetanocin, A Novel Nucleoside from Bacteria, J. Antibiotics, 39(11), 1623 (1986).
Shealy et al., Synthesis and Antiviral Activity of Carbocyclic Analogues of 2'-Deoxyribofuranosides of 2-Amino-6-substituted-purines and of 2-Amino-6-substituted-8-azapurines, J. Med. Chem., 27, 1416 (1984).
Secrist et al., Resolution of Racemic Carbocyclic Analogues of Purine Nucleosides through the Action of Adenosine Deaminase Antiviral Activity of the Carbocyclic 2'-Deoxyguanosine Enantiomers, J. Med. Chem., 30, 746 (1987).
Canning et al., Synthesis and Antiviral Activity of 9-[Cis]-2-[Hydroxymethyl)-Cyclopropmethyl]Guanine and Related Compounds, ACS National Meeting, 1986, (Abstract No. 33).
Nakamura, et al., The X-Ray Structure Determination of Oxetanocin, J. Antibiotics, 39, 1626-1629 (1986).
Niitsuma, et al. Studies on the Total Synthesis of Oxetanocin; I. The First Synthesis of a Nucleoside Having Oxetanosyl-N-Glycoside, Tetrahedron Letters, 28, 3967-3970 (1987).
Niitsuma, et al., Studies on the Total Synthesis of Oxetanocin; II. Total Synthesis of Oxetanocin; Tetrahedron Letter, 28, 4713 (1987).
Austin, et al., Chiral Oxetanes from Sugar Lactones: Synthesis of Derivatives of 3,5-Anhydro-1,2-O-Isopropylidene-D-Glucuronic Acid and of 3,5-Anhydro-1,2-O-Isopropylidene-B-L-Iduronic Acid, Tetrahedron Letters, 28, 4741-4744 (1987).
Shimada et al., Derivatives of Oxetanocin: Oxetanocins H, X and G, and 2-Aminooxetanocin A, J. Antibiotics, 40, 1788-1890 (1987).
Y. Nishiyama, et al., Selective Inhibition of Human Cytomegalovirus Replication by a Novel Nucleoside, Oxetanocin G, 32(7), 1053 (1988).
D. Norbeck, et al., Synthesis of (-)-Oxetanocin, J. Am. Chem. Soc., 110, 7217 (1988).
S. Nishiyama, et al., Synthetic Studies on Oxetanocin, A Novel Nucleside with an Oxetane Ring Synthesis of Some Chiral D-Oxetanosyl Acylates, Tetrahedron Letters, 29(37), 4739 (1988).
S. Nishiyama, et al., A Total Synthesis of Oxetanocin, A Novel Nucleoside with an Oxetane Ring, Tetrahedron Letters, 29(37), 4743, (1988).
Derwent Abstract No. 87-296034/42 of Japanese Specification JP-048499 published Sep. 12, 1987.

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