Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1996-10-04
1998-03-31
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544118, 544265, A61K 3152, C07D47330
Patent
active
057340536
ABSTRACT:
##STR1## Compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl; R.sup.2 is C.sub.2 -C.sub.4 alkyl; R.sup.3 is H or SO.sub.2 NR.sup.4 R.sup.5 ; R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino or 4-N-(R.sup.6)-1-piperazinyl group; and R.sup.6 is H or C.sub.1 -C.sub.3 alkyl; are selective cGMP PDE inhibitors useful in the treatment of, inter alia, cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.
REFERENCES:
patent: 2705715 (1955-04-01), Baker
patent: 5073559 (1991-12-01), Coates
Morrison and Boyd, Organic Chemistry, 858-859 (Allyn & Bacon 3rd Ed.) (1972).
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 34 (Ed. Gilman, Rall, Nies and Taylor; McGraw Hill 8th Ed.)(1990).
Berch Mark L.
Butterfield Garth
Ginsburg Paul H.
Pfizer Inc
Richardson Peter C.
LandOfFree
Purinone antianginal agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Purinone antianginal agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purinone antianginal agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-53458