Purinone antianginal agents

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544118, 544265, A61K 3152, C07D47330

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active

057340536

ABSTRACT:
##STR1## Compounds of formula (I), and pharmaceutically acceptable salts thereof, wherein R.sup.1 is C.sub.1 -C.sub.4 alkyl; R.sup.2 is C.sub.2 -C.sub.4 alkyl; R.sup.3 is H or SO.sub.2 NR.sup.4 R.sup.5 ; R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, morpholino or 4-N-(R.sup.6)-1-piperazinyl group; and R.sup.6 is H or C.sub.1 -C.sub.3 alkyl; are selective cGMP PDE inhibitors useful in the treatment of, inter alia, cardiovascular disorders such as angina, hypertension, heart failure and atherosclerosis.

REFERENCES:
patent: 2705715 (1955-04-01), Baker
patent: 5073559 (1991-12-01), Coates
Morrison and Boyd, Organic Chemistry, 858-859 (Allyn & Bacon 3rd Ed.) (1972).
Goodman and Gilman, The Pharmacological Basis of Therapeutics, 34 (Ed. Gilman, Rall, Nies and Taylor; McGraw Hill 8th Ed.)(1990).

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