Purinergic receptor

Details Purinergic receptor Purinergic receptor

1997-04-28

2000-10-17

Spector, Lorraine

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530350, C07H 2100, C07K 14475

Patent

active

061334340

ABSTRACT:
The present invention relates, in general, to a purinergic receptor and, in particular, to a P2X.sub.7 (also designated P2Z) receptor. The invention further relates to a nucleic acid encoding the P2X.sub.7 receptor and to a method of producing P2X.sub.7 recombinantly using same. The invention also relates to a method of screening compounds for their ability to inhibit P2X.sub.7 activity and thereby for their usefulness in treating a variety of diseases/disorders, including arthritic and respiratory disorders and neurodegenerative diseases.

REFERENCES:
patent: 5360893 (1994-11-01), Owens et al.
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GenBank Accession No. X95882, R. novegicus mRNA for ATP ligand gate ion channel, accessed Dec. 20, 1998, Jun. 1996.
Humphreys et al., Induction of the P2Z/P2X7 nucleotide receptor and associated phospholipase D activity by lipopolysaccharide and INF-gamma in the human THP-1 monocytic cell line, J. Immunol., 157(12): 5627-5637, Dec. 1996.
Di Virgilio et al., A purinergic hypothosis for immunomoldulation, Ital. J. Biochem., 45(4): 195-203, Dec. 1996.
Dubyak et al., Expression of multiple ATP receptor subtypes during the differentiation and inflammatory activation of myeloid leukocytes, Drug Dev. Res., 39: 269-278 (1996).
Wiley et al., The P2z-purinoceptor of human lymphocytes: actions of nucleotide agonists and irreversible inhibition by oxidized ATP, Br. J. Pharmacol., 112: 946-950 (1994).
Valera et al., Characerization and chromosomal localization of a human P2X receptor from urinary bladder, Receptors and Channels, 3(4):283-289, 1995.
An ATP-gated cation channel with some P2Z-like characteristics in gastric muscle cells of toad, J. Physiol., 498(Pt 2): 427-442, Jan. 1997.
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Valera et al., "A New Class of Ligand-Gated Ion Channel Defined by P.sub.2X Receptor for Extracellular ATP", Nature, vol. 371, Oct. 6, 1994, pp. 516-519.

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