Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-04-03
2007-04-03
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C536S027620, C536S027630, C536S027700, C536S027600, C536S027220, C514S045000, C514S046000, C544S276000, C544S277000, C549S050000, C549S435000, C549S448000
Reexamination Certificate
active
10530552
ABSTRACT:
Disclosed are purine nucleoside compounds that are selective to A3adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof:wherein X is sulfur or oxygen; R1is hydrogen, alkyl, benzyl, halobenzyl, or phenylalkyl; R2is hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio, or thio; R3and R3′ are hydrogen, hydroxyalkyl, alkoxycarbonyl, or alkylaminocarbonyl, whereas R3and R3′ do not have identical substituents simultaneously; and R4is hydrogen or alkyl. Also disclosed are a pharmaceutical composition comprising a compound of formula (I), an isomer, or its pharmacologically acceptable salt as an active ingredient and a method for preventing or treating various diseases, state, or condition, including asthma, inflammation, cerebral ischemia, heart diseases, and cancer.
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Jacobson Kenneth A.
Jeong Lak Shin
Kim Hea Ok
Moon Hyung Ryong
Berch Mark L.
Ewha Womans University
United States of America, Represented by the Secretary, Departme
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