Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosph

Details Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosph Purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosph

1977-04-27

1979-02-27

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

195 28N, 536 28, 536 29, 424181, A61K 3170, C07H 1920

Patent

active

041419723

ABSTRACT:
New purine nucleoside 5'-phosphate (mono, di or tri) 3'(2')-diphosphates and the sodium, lithium and potassium salts thereof are elaborated by the enzymatic transfer of pyrophosphoryl group from ATP (adenosine triphosphate), dATP (deoxyadenosine triphosphate) and pppApp (adenosine 5'-triphosphate 3'(2') diphosphate) to specified 5'-purine nucleotides, and a new nucloetide pyrophosphotransferase used for this enzyme reaction is produced by actinomycetes and other microorganisms and recovered from the culture filtrate and mycelium by the conventional methods for recovering enzymes. These compounds are useful for treating leukemia L1210 in mice.

REFERENCES:
patent: 3407190 (1968-10-01), Honjo et al.
patent: 3413282 (1968-11-01), Yoshikawa et al.
patent: 3423399 (1969-01-01), Honjo et al.
patent: 3457254 (1969-07-01), Yano et al.
patent: 3475409 (1969-10-01), Ouchi et al.
Berger, "Biochimica et Biophysica Acta", vol. 20, 1956, pp. 23-26.

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