Purine derivatives, preparation method and use as medicines

Details Purine derivatives, preparation method and use as medicines Purine derivatives, preparation method and use as medicines

2006-05-09

2006-05-09

Berch, Mark L. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C514S263400

Reexamination Certificate

active

07041824

ABSTRACT:
The use of purine derivatives of formula (I):in which:Rx is —(Z)n—R1whereinZ is a divalent radical selected from —CH2—, —SO2—, —CO—, —COO—, —CONH— and —(CH2)2—NR6—,n is the an integer selected from 0 and 1,R1is selected from hydrogen, aryl, —CH2-aryl, —SO2-aryl, heterocyclic, —CH2-heterocyclic, alkyl and —SO2-alkyl,Ry is a phenyl radical (optionally substituted) or the radical:wherein D1and D2, which are identical or different are selected from hydrogen, hydroxyl, the linear or branched alkyl or alkoxy radicals containing at most 6 carbon atoms and NHR5, or, alternatively, taken together, D1and D2form a radical selected from ═O and ═N—OR4,R4is hydrogen, alkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, cycloalkyl or aryl,R5is hydrogen, alkyl, cycloalkyl, or —COOtBu (Boc), andR6is hydrogen, alkyl or cycloalkyl, wherein the alkyl moiety contains 1 to 6, optionally substituted, carbon atoms;as cdk kinase inhibitors for the prevention and treatment of fungal infections. Also disclosed are novel methods and intermediates for the production of compounds of formula I, as well as pharmaceutical compositions containing said compounds.

REFERENCES:
patent: 5866702 (1999-02-01), Mackman et al.
patent: 6413754 (2002-07-01), Fay et al.
patent: 6413975 (2002-07-01), Chasin et al.
patent: 6479487 (2002-11-01), Dumont et al.
patent: 6667311 (2003-12-01), Trova
patent: 6812232 (2004-11-01), Trova
patent: WO 97/16452 (1997-05-01), None
patent: WO 97/20842 (1997-06-01), None
patent: WO 98/05335 (1998-02-01), None
patent: WO 99/07705 (1999-02-01), None
patent: WO 99/07836 (1999-02-01), None
patent: WO 00/49018 (2000-08-01), None
Kozima S et al., Formation of Organotin-Nitrogen Bonds III*, N-Trialkyltin-5-Substituted Tetrazoles, J. Organometallic Chemistry, vol. 33, 1971, pp 337-346.

Affiliated with

Also associated with

Rating

Purine derivatives, preparation method and use as medicines does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Purine derivatives, preparation method and use as medicines, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Purine derivatives, preparation method and use as medicines will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3648223