Purine derivatives having cyclopropane ring

Details Purine derivatives having cyclopropane ring Purine derivatives having cyclopropane ring

1998-11-03

2000-12-05

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Pteroyl per se or having -c-, wherein x is chalcogen, bonded...

544265, 544276, 544277, C07D47340, C07D47318, C07D47330, C07D47332, C07D47300

Patent

active

061568929

ABSTRACT:
A purine derivative having a cyclopropane ring represented by the formula (I): ##STR1## wherein A is --CH.sub.2 -- group or --CO-- group; X.sup.1 is hydrogen atom, a halogen atom, an alkoxy group having 1 to 10 carbon atoms, or hydroxyl group; each of X.sup.2, X.sup.3, and X.sup.4 is independently hydrogen atom or a halogen atom; R.sup.1 is hydrogen atom, a halogen atom, or a protected or unprotected amino group; and each of R.sup.2 and R.sup.3 is independently hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 7 carbon atoms, a substituted or unsubstituted aralkyl group, having 7 to 11 carbon atoms, or a substituted or unsubstituted acyl group having 1 to 7 carbon atoms, with proviso that in a case where A is --CO-- group, neither R.sup.2 nor R.sup.3 is a substituted or unsubstituted acyl group having 1 to 7 carbon atoms, and each of X.sup.3 and X.sup.4 is independently a halogen atom, and a process for preparing the same.

REFERENCES:
patent: 3495012 (1970-02-01), Minieri et al.
patent: 4988703 (1991-01-01), Norbeck et al.
Izawa, J. Chem Soc, Perkins 1, p. 2519, 1992.
Kato, Chem Abs 118: 255264m, Oct. 1992.
Geen et al., Bioorganic & Medicinal Chemistry Letters, vol. 1, No. 7, pp. 347-348 (1991).
Choudary et al., Nucleosides & Nucleotides, vol. 15, No. 5, pp. 981-994 (1996).

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