Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Patent
1992-01-22
1993-10-05
Rizzo, Nicholas S.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
544276, C07D47334, A61K 3152
Patent
active
052506886
ABSTRACT:
A compound of formula (I) ##STR1## or a salt thereof, wherein R.sub.1 and R.sub.2 are each independently hydrogen, acyl or phosphate, provided that when one of R.sub.1 or R.sub.2 is phosphate, the other is hydrogen; or R.sub.1 and R.sub.2 are joined together to form a cyclic acetal group, a cyclic carbonate group or a cyclic phosphate group.
Processes for preparing these compounds and their use in therapy is also described.
REFERENCES:
patent: 4579849 (1986-04-01), MacCess et al.
patent: 4609662 (1986-09-01), Kaenitsky
Gillen, Sythesis and Properties of Novel Nucleoside and Nucleotide Analogues (Apr. 19, 1980).
Bandit et al., Synthetic Communications 2(6) 345-351 (1972).
Tippie, M. A., et al., "Antiherpes Simplex Activity of 9-[Hydroxy-3-(hydroxymethyl)-1-butylguanine", Nucleosides and Nucleotides 3,(5),525-535 (1984).
Harnden Michael R.
Jarvest Richard L.
Beecham Group p.l.c.
Lentz Edward T.
Rizzo Nicholas S.
Stercho Yuriy P.
Suter Stuart R.
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