Purine Derivatives

Details Purine Derivatives Purine Derivatives

1989-08-29

1991-01-01

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514262, 544267, C07D47306, A61K 3152

Patent

active

049818570

ABSTRACT:
The present invention relates to certain novel 8-phenylxanthines substituted in the 3 or 4 position of the phenyl group by an alkenylene, alkenyleneoxy, alkynylene or alkynyleneoxy bearing a terminal acidic grouping, and to their use in human and veterinary therapy, particularly for conditions associated with the cell surface effects of adenosine.

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Life Science, vol. 28, pp. 2083-2097, Daly et al., Adenosine Receptors and Methylaxanthines, No. 19, 1981.
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Robert F. Bruns, pp. 325-333, Adenosine Antagonism by Purines, Pteridines and Benzopteridines in Human Fibroblasts.
Bruns et al., Proc. Nat'l. Acad. Sci, U.S.A., vol. 80, pp. 2077-2080, Apr. 1983, Neurobiology, Adenosine Receptor Binding: Structure-Activity Analysis Generates Extremely Patent Xanthine Antagonists.
J. Org. Chem., 1951, 16, pp. 1879-1890, Papesch et al., Synthesis of 1-Mono- and 1,3-Di-Substituted 6-Amino-Uracils. Diuretic Activity.sup.1.
Cir. Res., 1982, 51, pp. 569.579, Belardinelli et al., Extracellular Action of Adenosine and the Antagonism by Aminophylline on the Atrioventricular Conduction of Isolated Perfused Guinea Pig and Rat Hearts.
J. Chem. Soc., 1962, pp. 1863-1868, Wooldridge and Slack, The Synthesis of Some 6-Thioxanthines.
J. Med. Chem., 1967, 10, pp. 833-840, Short et al., Sympathetic Nervous System Blocking Agents, III. Derivatives of Benzylguanidine.sup.1-3.
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