Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-08-14
2007-08-14
Berch, Mark L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S264000, C544S265000, C544S276000, C544S277000, C544S118000, C544S247000, C514S263300, C514S263370, C514S263380, C514S263400
Reexamination Certificate
active
11006095
ABSTRACT:
The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 2,8,9-substituted purines and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.
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Thompson, R.D. et al., “N6,9-Disubstituted Adenines: Potent, Selective Antagonists at the A1Adenosine Receptor”,J. Med. Chem.,1991, pp. 2877-2882, vol. 34.
Nagano, H. et al., “Fluorine-Containing Potential Anticancer Agents. II. Syntheses of Some Trifluoromethylpurines and Trifluoromethylthiazolopyrimidines”,J Med Chem.,1964, pp. 215-220, vol. 7, No. 2.
Koppel, H. et al., “Potential Purine Antagonists. XI Synthesis of Some 9-Aryl(alkyl)-2, 6-disubstituted Purines”,J. Amer. Chem. Soc.,1958, pp. 2751-2755, vol. 80.
Brugel Todd Andrew
Clark Michael Philip
De Biswanath
Golebiowski Adam
Sabat Mark
Berch Mark L.
Paul Andrew A.
The Procter & Gamble & Company
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