Purine cytokine inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S264000, C544S265000, C544S276000, C544S277000, C544S118000, C544S247000, C514S263300, C514S263370, C514S263380, C514S263400

Reexamination Certificate

active

11006095

ABSTRACT:
The present invention relates to 2,8,9-substituted purines which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 2,8,9-substituted purines and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.

REFERENCES:
patent: 3133065 (1964-05-01), Carbon
patent: 6579868 (2003-06-01), Asano et al.
patent: 2006/0287344 (2006-12-01), Albers et al.
patent: 2007/0060598 (2007-03-01), Albers et al.
patent: WO 2005/016528 (2005-02-01), None
Thompson, R.D. et al., “N6,9-Disubstituted Adenines: Potent, Selective Antagonists at the A1Adenosine Receptor”,J. Med. Chem.,1991, pp. 2877-2882, vol. 34.
Nagano, H. et al., “Fluorine-Containing Potential Anticancer Agents. II. Syntheses of Some Trifluoromethylpurines and Trifluoromethylthiazolopyrimidines”,J Med Chem.,1964, pp. 215-220, vol. 7, No. 2.
Koppel, H. et al., “Potential Purine Antagonists. XI Synthesis of Some 9-Aryl(alkyl)-2, 6-disubstituted Purines”,J. Amer. Chem. Soc.,1958, pp. 2751-2755, vol. 80.

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